- Clone
- 1D10B31 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Interleukin-31
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
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659607 | 25 tests | 118€ | ||||
659608 | 100 tests | 296€ |
IL-31, produced mainly by activated CD4+ T cells, is a newly discovered helical cytokine belonging to the gp130/IL6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Human IL-31 is also involved in inflammatory bowel disease, airway hypersensitivity, and dermatitis.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Full length human IL-31 recombinant protein expressed in E. coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 488 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
* Alexa Fluor® 488 has a maximum emission of 519 nm when it is excited at 488 nm.
Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.
View full statement regarding label licenses - Excitation Laser
-
Blue Laser (488 nm)
- RRID
-
AB_2616660 (BioLegend Cat. No. 659607)
AB_2616660 (BioLegend Cat. No. 659608)
Antigen Details
- Structure
- 161 aa with with a putative 23 aa signal peptide that is cleaved to generate a 138 aa mature protein.
- Distribution
- Secreted by activated CD4 T cells.
- Function
- IL-31 belongs to the IL-6 family of cytokines and plays a role in skin inflammation.
- Ligand/Receptor
- Binds to IL-31 receptor complex that consists of two receptor subunits, IL31RA and OSMR.
- Cell Type
- T cells, Eosinophils
- Biology Area
- Cell Biology, Immunology
- Molecular Family
- Cytokines/Chemokines
- Antigen References
-
1. McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42.
2. Arai I, et al. 2013. Exp. Dermatol. 22:669.
3. Dai X, et al. 2013. PLoS One. 8:e67666.
4. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446.
5. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232.
6. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5. - Gene ID
- 386653 View all products for this Gene ID
- UniProt
- View information about IL-31 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All IL-31 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human IL-31 | 1D10B31 | WB |
PE anti-human IL-31 | 1D10B31 | ICFC |
APC anti-human IL-31 | 1D10B31 | ICFC |
Alexa Fluor® 488 anti-human IL-31 | 1D10B31 | ICFC |
PE/Cyanine7 anti-human IL-31 | 1D10B31 | ICFC |
TotalSeq™-B1160 anti-human IL-31 | 1D10B31 | ICPG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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-
Purified anti-human IL-31
20 ng of human IL-31 recombinant protein was resolved by ele... -
PE anti-human IL-31
Six hours PMA + Ionomycin-stimulated human peripheral blood ... -
APC anti-human IL-31
PMA+ionomycin-stimulated (in the presence of monensin, 6hrs)... -
Alexa Fluor® 488 anti-human IL-31
Six hours PMA + Ionomycin-stimulated human peripheral blood ... -
PE/Cyanine7 anti-human IL-31
Human peripheral blood mononuclear cells were treated with C... -
TotalSeq™-B1160 anti-human IL-31
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