APC anti-human CD144 Recombinant Antibody, CD144, QA20A44

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Clone: QA20A44 (See other available formats)
Regulatory Status: RUO
Other Names: VE-Cadherin, cadherin-5, CDH5
Isotype: Mouse IgG1, κ
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Product Citations: publications

QA20A44_APC_CD144_Antibody_020924 — HUVEC cells were surface stained with anti-human CD144 recombinant (clone QA20A44) APC (filled histogram) or mouse IgG1, κ APC isotype control (open histogram).

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376507

25 tests

100€

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Description

CD144, also known as VE-cadherin and cadherin-5, is a 140 kD glycoprotein which is composed of five extracellular cadherin repeats and a highly conserved cytoplasmic tail region. It is a calcium-dependent transmembrane cell-cell adhesion molecule localized at the intercellular boundaries of endothelial cells, hematopoietic stem cells, and perineurial cells. It functions as a classic cadherin by mediating homophilic adhesion and functions as a plasma membrane attachment site for the cytoskeleton. CD144 is thought to play a role in vascular development, permeability, and remodeling.

Product Details

Technical Data Sheet (pdf)

Product Details

Verified Reactivity: Human
Antibody Type: Recombinant
Host Species: Mouse
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
RRID: AB_3106048 (BioLegend Cat. No. 376507)

Antigen Details

Structure: Member of the cadherin family; calcium-dependent transmembrane cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats and a highly conserved cytoplasmic tail region.
Distribution: Endothelial cells, hematopoietic stem cells, perineurial cells
Function: Mediates calcium-dependent homophilic cell adhesion, plays fundamental roles in microvascular permeability and in the morphogenic and proliferative events associated with angiogenesis
Cell Type: Endothelial cells
Biology Area: Cell Adhesion, Cell Biology, Immunology
Molecular Family: Adhesion Molecules, CD Molecules
Antigen References: 1. Taddei A, et al. 2008. Nat. Cell Biol. 10:923.
2. Gavard J, et al. 2006. Nat. Cell Biol. 8:1223.
3. Kim I, et al. 2005. Blood 106:903.
4. Suzuki S, et al. 1991. Cell Regul. 2:261.
Gene ID: 1003 View all products for this Gene ID
UniProt: View information about CD144 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD144 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD144 Recombinant Antibody	QA20A44	FC
PE anti-human CD144 Recombinant Antibody	QA20A44	FC
PE/Cyanine7 anti-human CD144 Recombinant Antibody	QA20A44	FC
APC anti-human CD144 Recombinant Antibody	QA20A44	FC
FITC anti-human CD144 Recombinant Antibody	QA20A44	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 02/09/2024

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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