- Clone
- QA19A18 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD222, Insulin-like growth factor 2 Receptor (IGF2R), Cation-independent mannose 6-phosphate receptor (CIMPR), or Mannose-6 phosphate receptor (M6PR)
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
364205 | 25 tests | 76€ | ||||
364206 | 100 tests | 176€ |
QA19A18 recombinant antibody binds to CD222 in human, which is also known as the Insulin-like growth factor 2 receptor (IGF2R), cation-independent mannose-6-phosphate receptor (CIMPR), and mannose-6 phosphate receptor (M6PR). CD222 is a type I transmembrane glycoprotein present largely intracellularly in the Golgi apparatus and endosomal compartments, but also at the cell surface. CD222 is expressed ubiquitously in a vast majority of higher eukaryotic cell types and the central component of endosomal transport pathways. The variety of CD222 ligands implicates that CD222 plays important functions in many pathological processes, such as biogenesis of lysosomes, regulation of IGF2, LTGFβ activation, etc. Loss of CD222 is associated with inhibition of T effector cell function.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
FC - Verified - Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Red Laser (633 nm)
- Product Citations
-
- RRID
-
AB_2904389 (BioLegend Cat. No. 364205)
AB_2904389 (BioLegend Cat. No. 364206)
Antigen Details
- Structure
- Type I transmembrane glycoprotein
- Distribution
-
Ubiquitously expressed on many cell types (Monocytes/Granulocytes)
- Function
- Biogenesis of lysosomes, embryogenesis, cell migration
- Interaction
- DPP4, heterotrimeric retromer cargo-selection complex (CSC)
- Ligand/Receptor
- Insulin-like growth factors, latent TGF-β, leukemia inhibitory factor (LIF), proliferin, prorenin, plasminogen
- Molecular Family
- Growth Factors
- Antigen References
-
- Leksa V, et al. 2017. Immunol Lett. 190:194.
- Pfisterer K, et al. 2014. J Immunol. 193:2718.
- Wood R, et al. 2008. J Biol Chem.
- Gene ID
- 3482 View all products for this Gene ID
- UniProt
- View information about CD222 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All CD222 (IGF2R) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD222 (IGF2R) Recombinant Antibody | QA19A18 | ICFC,FC |
APC anti-human CD222 (IGF2R) Recombinant Antibody | QA19A18 | ICFC,FC |
FITC anti-human CD222 (IGF2R) Recombinant Antibody | QA19A18 | ICFC,FC |
PE anti-human CD222 (IGF2R) Recombinant Antibody | QA19A18 | ICFC,FC |
TotalSeq™-B1453 anti-human CD222 (IGF2R) Recombinant Antibody | QA19A18 | ICPG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD222 (IGF2R) Recombinant Antibody
Human peripheral blood lymphocytes were stained with anti-hu... -
APC anti-human CD222 (IGF2R) Recombinant Antibody
Human peripheral blood mononuclear cells were fixed, permeab... -
FITC anti-human CD222 (IGF2R) Recombinant Antibody
Human peripheral blood mononuclear cells were fixed, permeab... -
PE anti-human CD222 (IGF2R) Recombinant Antibody
Human peripheral blood mononuclear cells were fixed, permeab... -
TotalSeq™-B1453 anti-human CD222 (IGF2R) Recombinant Antibody
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