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APC anti-human CD307e (FcRL5) Antibody

Pricing & Availability
Clone
509f6 (See other available formats)
Regulatory Status
RUO
Other Names
CD307, IRTA2, FcRH5, IFGP5, BXMAS1
Isotype
Mouse IgG2a, κ
Ave. Rating
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Product Citations
publications
509F6_APC_CD307e_Antibody_FC_092514
Human FcRL5 transfected P815 cell line was stained with CD307e (clone 509F6) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
  • 509F6_APC_CD307e_Antibody_FC_092514
    Human FcRL5 transfected P815 cell line was stained with CD307e (clone 509F6) APC (filled histogram) or mouse IgG2a, κ APC isotype control (open histogram).
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340305 25 tests 120€
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340306 100 tests 300€
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Description

FcRL5, also known as CD307e, CD307, IRTA2, FcRH5, and BXMAS1, is a 106 kD type I transmembrane glycoprotein composed of six-eight extracellular Ig like C2 domains and two cytoplasmic ITIM motifs. The FcRL5 gene is located on chromosome 1q21 and is normally expressed by tonsillar plasma cells and germinal center B cells. It has been suggested that FcRL5 contributes to B cell maturation and B cell receptor modulation. The identification of FcRL5 on a number of transformed cell types including hairy cell leukemia, mantle cell lymphoma, chronic lymphocytic lymphoma, and Burkitt’s lymphoma has prompted interest in it as a potential biomarker or target for immunotherapy. FcRL5 binds all aggregated IgG isotypes.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
P815 cells transfected with FcRL5
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunoprecipitation and blocking1. mAb 509f6 is able to block the binding of FcRL5 to all aggregated IgG isotypes.1

Application References
  1. Wilson TJ, et al. 2012. J. Immunol. 188:4741. (Block)
Product Citations
  1. SoRelle ED, et al. 2022. Front Immunol. 13:1001145. PubMed
  2. Hata K, et al. 2023. Front Immunol. 14:1145814. PubMed
  3. Jiang D, et al. 2023. Nat Commun. 14:3642. PubMed
  4. Sutton HJ, et al. 2021. Cell Reports. 34(6):108684. PubMed
  5. Csomós K, et al. 2022. Nat Immunol. 23:1256. PubMed
  6. Wang J, et al. 2020. Cell. 183(7):1867-1883.e26. PubMed
RRID
AB_2564326 (BioLegend Cat. No. 340305)
AB_2564326 (BioLegend Cat. No. 340306)

Antigen Details

Structure
106 kD, Fc receptor like, type 1 transmembrane protein, 6-8 Ig like C2 domains, 2 cytoplasmic ITIM motifs.
Distribution

Germinal center B cells, tonsillar plasma cells.

Ligand/Receptor
Aggregated IgG
Cell Type
B cells, Plasma cells
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Davis R, et al. 2007. Annu. Rev. Immunol. 207:528.
2. Mohan J, et al. 2006. Blood 107:4433.
3. Ise T, et al. 2007. Leukemia. 21:169.

Gene ID
83416 View all products for this Gene ID
UniProt
View information about CD307e on UniProt.org
Go To Top Version: 2    Revision Date: 10/27/2014

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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