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Brilliant Violet 711™ anti-human XCR1 Antibody

Pricing & Availability
Clone
S15046E (See other available formats)
Regulatory Status
RUO
Other Names
GPR5, CCXCR1, mXCR1, Lymphotactin receptor, SCM1 receptor, XC chemokine receptor 1
Isotype
Rat IgG2a, κ
Ave. Rating
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Product Citations
publications
S15046E_BV711_XCR1_Antibody_1_071124
Human peripheral blood mononuclear cells were stained with Pacific Blue™ anti-human Lineage Cocktail, anti-human CD141 (clone M80) PE and anti-human XCR1 (clone S15046E) Brilliant Violet 711™ (left) or rat IgG2a, κ Brilliant Violet 711™ isotype control (right). Data shown was gated on the lineage negative cells; the gate in the dot plot denotes XCR1+ cells.
  • S15046E_BV711_XCR1_Antibody_1_071124
    Human peripheral blood mononuclear cells were stained with Pacific Blue™ anti-human Lineage Cocktail, anti-human CD141 (clone M80) PE and anti-human XCR1 (clone S15046E) Brilliant Violet 711™ (left) or rat IgG2a, κ Brilliant Violet 711™ isotype control (right). Data shown was gated on the lineage negative cells; the gate in the dot plot denotes XCR1+ cells.
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372633 25 tests 177€
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372634 100 tests 348€
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Description

XCR1, also known as GPR5 or CCXCR1, is a 38 kD G-protein coupled, seven transmembrane receptor. It is the only member of the "C" chemokine receptor family and mediates chemotaxis of XCL1 and XCL2 (lymphotactin-1 and -2). XCR1 is expressed on a subset of CD141+ conventional dendritic cells. XCR1 is also involved in the migration and proliferation of some cancer cells.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Human XCR1-transfected cells.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with Brilliant Violet 711™ under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

Brilliant Violet 711™ excites at 405 nm and emits at 711 nm. The bandpass filter 710/50 nm is recommended for detection, although filter optimization may be required depending on other fluorophores used. Be sure to verify that your cytometer configuration and software setup are appropriate for detecting this channel. Refer to your instrument manual or manufacturer for support. Brilliant Violet 711™ is a trademark of Sirigen Group Ltd.


Learn more about Brilliant Violet™.

This product is subject to proprietary rights of Sirigen Inc. and is made and sold under license from Sirigen Inc. The purchase of this product conveys to the buyer a non-transferable right to use the purchased product for research purposes only. This product may not be resold or incorporated in any manner into another product for resale. Any use for therapeutics or diagnostics is strictly prohibited. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.
Excitation Laser
Violet Laser (405 nm)
RRID
AB_3662275 (BioLegend Cat. No. 372633)
AB_3662275 (BioLegend Cat. No. 372634)

Antigen Details

Structure
Only member of the "C" chemokine receptor family, seven transmembrane receptor, coupled to G protein, 38 kD.
Distribution

Subset of CD141+ conventional dendritic cells.

Function
Mediates chemotaxis to XCL1.
Ligand/Receptor
XCL1 and XCL2.
Cell Type
Dendritic cells
Biology Area
Immunology
Molecular Family
Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Carpentier S, et al. 2016. J. Immunol. Methods 432:35.
2. Hartung E, et al. 2015. J. Immunol. 194:1069.
3. Wang T, et al. 2015. Biochem. Biophys. Res. Commun. 464:635.
4. Crozat K, et al. 2011. J. Immunol. 187:4411.

Gene ID
2829 View all products for this Gene ID
UniProt
View information about XCR1 on UniProt.org
Go To Top Version: 1    Revision Date: 07/11/2024

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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