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PE anti-human CD344 (Frizzled-4) Antibody

Pricing & Availability
Clone
CH3A4A7 (See other available formats)
Regulatory Status
RUO
Other Names
Frizzled-4 receptor, Frizzled-4, Fz4, FZD4, FzE4, hFz4, FEVR, EVR1
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
CH3A4A7_PE_022309.jpg
Human cervical cancer cell line Hela stained with CH3A4A7 PE
  • CH3A4A7_PE_022309.jpg
    Human cervical cancer cell line Hela stained with CH3A4A7 PE
See PE spectral data
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326605 25 tests 117€
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326606 100 tests 254€
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Description

CD344 is a member of the Frizzled family, known as Frizzled-4 (Fz4, FZD4, hFz4, or FzE4). Ten frizzled member have been identified in humans. Human FZD4 gene has been mapped to chromosome 11q14-q21. FZD4 is a 48-53 kD seven transmembrane G-protein-coupled receptor (GPCR), a receptor for Wnt proteins and norrie. It is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). FZD4 is a neuronal stem cell marker and is also expressed on fetal neuronal progenitor cells and neuronal intestinal cells. Kidney, lung, brain and liver express abundant of FZD4. It has been reported that FZD4 controls retinal and inner ear angiogenesis, participates in the regulation of embryonic development, tissue and cell polarization and proliferation.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Cynomolgus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
WERI-RB-1 retinoblastoma cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID
AB_2109243 (BioLegend Cat. No. 326605)
AB_2109243 (BioLegend Cat. No. 326606)

Antigen Details

Structure
Frizzled family, seven transmenbrane G-protein-coupled receptor, 48-53 kD
Distribution

Kidney, lung, brain, liver, neuronal stem cells, fetal neuronal progenitor cells and neuronal intestinal cells

Function
Embryonic development, tissue/cell polarization and proliferation
Ligand/Receptor
Norrie, Wnt proteins
Biology Area
Angiogenesis, Cell Biology, Immunology
Molecular Family
CD Molecules
Antigen References

1. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers Wiley-Liss A John Wiley & Sons Inc, Publication
2. Kirikoshi H, et al. 1999. Biochem. Biophys. Res. Commun. 264:955.
3. Smallwood PM, et al. 2007. J. Biol. Chem. 282:4057.

Gene ID
8322 View all products for this Gene ID
UniProt
View information about CD344 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 2    Revision Date: 08/25/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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