- Clone
- W20099D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase
- Isotype
- Rat IgG2b, λ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
335853 | 25 tests | 100€ | ||||
335854 | 100 tests | 260€ |
IDO1 is also known as Indolamine 2,3-dioxygenase, Indole 2,3-dioxygenase, and Indoleamine-pyrrole 2,3-dioxygenase. IDO1 is a ubiquitously expressed cytoplasmic protein with a predicted molecular weight of approximately 45 kD. It is one of the best known IFN-γ inducible genes. The product of IDO gene catalyzes the degradation of the essential amino acid L-tryptophan to N-formylkynurenine. IDO has been implicated to protect against intracellular and extracellular pathogens. It also has been shown to maintain the special immune suppressive status of immune-privileged sites such as the brain, eyes, kidney, and placenta.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant protein, full length human IDO
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
ICFC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- RRID
-
AB_3662230 (BioLegend Cat. No. 335853)
AB_3662230 (BioLegend Cat. No. 335854)
Antigen Details
- Structure
- Heme-containing enzyme of 403 amino acids with a predicted molecular weight of 45 kD.
- Distribution
-
Cytoplasm
- Function
- Dioxygenase, Oxidoreductase
- Ligand/Receptor
- Heme, Iron, Metal binding
- Cell Type
- Dendritic cells, Eosinophils, Langerhans cells, Macrophages, Schwann Cells, T cells
- Biology Area
- Immuno-Oncology, Immunology, Inhibitory Molecules
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
- Yamazaki F, et al.1985. The Biochemical Journal. 230: 635–8.
- Prendergast GC, et al. 2014. Frontiers in Immunology. 5:585.
- Habara-Ohkubo A, et al. 1991. Gene. 105:221.
- Munn DH, et al. 2002. Science. 297:1867.
- Frumento G, et al. 2002. J Exp Med. 196:459.
- Muller AJ, et al. 2005. Nature Med. 11:312.
- Löb S, et al. 2009. Nature Rev Cancer. 9:445-52.
- Gene ID
- 15930 View all products for this Gene ID
- UniProt
- View information about IDO1 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All IDO1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
PE anti-human IDO1 | W20099D | ICFC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-human IDO1
LPS stimulated (24 hours) human peripheral blood mononuclear...
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