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PE/Cyanine7 anti-mouse CD192 (CCR2) Antibody

Pricing & Availability
Clone
SA203G11 (See other available formats)
Regulatory Status
RUO
Other Names
Ccr2, Ckr2, Ccr2a, Ccr2b
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
SA203G11_PECyanine7_CD192_Antibody_1_120623
C57BL/6 bone marrow was stained with Ly-6G APC, CD11b PE/Dazzle™ 594, and CD192 (clone SA203G11) PE/Cyanine7 (left) or rat IgG2b, κ PE/Cyanine7 isotype control (right). Dot plots are gated on Ly-6G- cells.
  • SA203G11_PECyanine7_CD192_Antibody_1_120623
    C57BL/6 bone marrow was stained with Ly-6G APC, CD11b PE/Dazzle™ 594, and CD192 (clone SA203G11) PE/Cyanine7 (left) or rat IgG2b, κ PE/Cyanine7 isotype control (right). Dot plots are gated on Ly-6G- cells.
Compare all formats See PE/Cyanine7 spectral data
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150611 25 µg 137€
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150612 100 µg 296€
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Description

CD192, also known as CCR2, is a 42 kD G-protein coupled receptor that is associated with bone marrow homeostasis. Specifically, CD192 mediates monocyte chemotaxis and acts as a receptor for monocyte chemoattractant protein 1 (MCP-1). CD192 is primarily expressed on monocytes and macrophages, with some expression on basophils. It is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis and cancer.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
Mouse CCR2 transfectants.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. van Dierendonck XAMH, et al. 2022. Proc Natl Acad Sci U S A. 119:e2114739119. PubMed
  2. Zhao M, et al. 2022. Nat Commun. 13:7600. PubMed
  3. Li T, et al. 2022. J Leukoc Biol. 112:845. PubMed
  4. Shen WY, et al. 2023. iScience. 26:106805. PubMed
  5. Karlen SJ, et al. 2018. J Neuroinflammation. 15:344. PubMed
  6. Weigert A, et al. 2022. Nat Commun. 13:6078. PubMed
  7. Trompette A, et al. 2022. Mucosal Immunol. :. PubMed
  8. Canedo T, et al. 2021. Neuropsychopharmacology. 46:2358. PubMed
  9. Liu SS, et al. 2021. Immunity. :. PubMed
  10. Schmit T, et al. 2022. Cell Rep. 38:110456. PubMed
  11. McGinley AM, et al. 2020. Immunity. 52(2):342-356. PubMed
  12. Aurélien Trompette et al. 2018. Immunity. 48(5):992-1005 . PubMed
RRID
AB_2616983 (BioLegend Cat. No. 150611)
AB_2616983 (BioLegend Cat. No. 150612)

Antigen Details

Structure
G-protein-coupled receptor, 7-transmembrane protein, 42 kD.
Distribution

Monocytes/macrophages and basophils.

Function
Mediator of monocyte chemotaxis and bone marrow homeostasis.
Ligand/Receptor
MCP-1, Ccl2, Ccl7, and Ccl13.
Cell Type
Basophils, Macrophages, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References

1. Mack M, et al. 2001. J. Immunol. 166:4697.
2. Dutta P, et al. 2015. Cell Stem Cell. 16:477.
3. Li L, et al. 2008. Kidney Int. 74:1526.

Gene ID
12772 View all products for this Gene ID
UniProt
View information about CD192 on UniProt.org
Go To Top Version: 1    Revision Date: 06/09/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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