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- Clone
- 6B11 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TCR Vα24-Jα18, TCR Vα24-JαQ, invariant NKT cell, iNKT
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with anti-human CD3 (clone UCHT1) Brilliant Violet 421™ and anti-human TCR Vα24-Jα18 (iNKT cell) (clone 6B11) PerCP/Fire™ 806 (left) or mouse IgG1, κ PerCP/Fire™ 806 isotype control (right).
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 342939 | 25 tests | 152€ | ||||
| 342940 | 100 tests | 344€ | ||||
Encoded by the TCR Vα24-Jα18 germline configuration, Vα24-JαQ is expressed on a subset of NKT cells, namely invariant NKT (iNKT). Vα24-JαQ TCR interacts with the glycolipid loaded MHC class 1b molecule CD1d, inducing activation and subsequent cytokine production. iNKT cells have been implicated in immune regulation, tumor surveillance, and host response to pathogens. While iNKT cells occur at low frequency in the blood, assorted chemokines contribute to their tissue homing potential.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- Rhesus, Pigtailed Macaque, Sooty Mangabey
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PerCP/Fire™ 806 under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
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FC - Quality tested
- Recommended Usage
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Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* PerCP/Fire™ 806 has a maximum excitation of 478 nm and a maximum emission of 806 nm. - Excitation Laser
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Blue Laser (488 nm)
- Application Notes
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The 6B11 antibody recognizes the invariant CDR3 region of TCR Va24-JaQ.
- Application References
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- Rout N, et al. 2010. PLoS One 5:e9787. (FC)
- RRID
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AB_3106112 (BioLegend Cat. No. 342939)
AB_3106112 (BioLegend Cat. No. 342940)
Antigen Details
- Structure
- Invariant CDR3 region of TCR Vα24-JαQ
- Distribution
-
Invariant NKT cells
- Ligand/Receptor
- Glycolipid loaded CD1d
- Cell Type
- NKT cells
- Biology Area
- Immunology
- Molecular Family
- TCRs
- Antigen References
-
- Thomas SY, et al. 2003. J. Immunol. 171:2571.
- Exley MA, et al. 2008. Eur. J. Immunol. 38:1756.
- Montoya CJ, et al. 2007. Immunology. 122:1.
- Gansuvd B, et al. 2003. J. Immunol. 171:2904.
- Gene ID
- 28659 View all products for this Gene ID
- UniProt
- View information about TCR Valpha24-Jalpha18 on UniProt.org
Related FAQs
Other Formats
View All TCR Vα24-Jα18 Reagents Request Custom ConjugationCompare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes stained with purified 6B1... 
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PE anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes stained with 6B11 PE and ...
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FITC anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes stained with 6B11 FITC (l... 
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APC anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes stained with 6B11 APC (lo... 
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PE/Cyanine7 anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... 
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PerCP/Cyanine5.5 anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... 
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Brilliant Violet 421™ anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... 
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Brilliant Violet 510™ anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... 
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PE/Dazzle™ 594 anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... 
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Brilliant Violet 711™ anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphoyctes were stained with CD3 FIT... 
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TotalSeq™-A0584 anti-human TCR Vα24-Jα18 (iNKT cell)
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TotalSeq™-C0584 anti-human TCR Vα24-Jα18 (iNKT cell)
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Brilliant Violet 605™ anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... -
Brilliant Violet 785™ anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... -
TotalSeq™-B0584 anti-human TCR Vα24-Jα18 (iNKT cell)
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APC/Fire™ 750 anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with CD3 FIT... -
APC/Cyanine7 anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes stained with anti-human C... -
PerCP/Fire™ 780 anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with anti-hu... -
PerCP/Fire™ 806 anti-human TCR Vα24-Jα18 (iNKT cell)
Human peripheral blood lymphocytes were stained with anti-hu... -
Spark Red™ 718 anti-human TCR Vα24-Jα18 (Flexi-Fluor™)
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Spark Blue™ 574 anti-human TCR Vα24-Jα18 (Flexi-Fluor™)
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Spark Blue™ 550 anti-human TCR Vα24-Jα18 (Flexi-Fluor™)
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