- Clone
- CPTC-FAF1-1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FAS-associated factor 1, hFAF1, UBX domain-containing protein 12, UBX domain-containing protein 3A, UBXD12, UBXN3A, Fas (TNFRSF6) Associated Factor 1, TNFRSF6-Associated Factor 1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
870601 | 25 µg | 85€ | ||||
870602 | 100 µg | 221€ |
FAS-associated factor 1 (FAF1) is an evolutionarily conserved protein with multiple protein interaction domains, including a FAS-interacting domain (FID), a death effector domain interacting domain (DEDID), and multi-ubiquitin-related domains. Initially identified as a member of FAS death-inducing signaling complex, FAF1 plays diverse roles in apoptotic and survival pathways. It may also serve as a scaffolding protein that regulates protein degradation in the ubiquitin-proteasome pathway. FAF1 is abundantly expressed in the brain where it modulates cell death. FAF1 also serves as a substrate for parkin, a key protein implicated in the pathogenesis of Parkinson’s disease (PD). Wild type parkin ubiquitinates FAF1 and promotes its degradation, while PD-linked mutant parkin causes abnormal accumulation of FAF1.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant full length protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.5 - 10 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2820196 (BioLegend Cat. No. 870601)
AB_2820196 (BioLegend Cat. No. 870602)
Antigen Details
- Structure
- Human FAF1 is a 650 amino acid protein with a predicted molecular mass of 74 kD.
- Distribution
-
Tissue distribution: Ubiquitously expressed
Cellular distribution: Plasma membrane, nucleus, cytosol, endoplasmic reticulum - Function
- FAF1 is an ubiquitin-binding protein, required for the progression of DNA replication forks.
- Interaction
- Interacts with CDT1, ATPase VCP/p97, FAS, and NLRP12.
- Cell Type
- Neurons
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Cycle/DNA Replication, Cell Death, Neuroscience, Ubiquitin/Protein Degradation
- Antigen References
-
- Menges CW, et al. 2009. Cell Cycle. 8(16):2528-34.
- Sul JW, et al. 2013. Hum Mol Genet. 22(8):1558-73.
- Cheng K, et al. 2011. J Neurosci. 31(33):11905-13.
- Gene ID
- 11124 View all products for this Gene ID
- UniProt
- View information about FAF1 on UniProt.org
Other Formats
View All FAF1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-FAF1 | CPTC-FAF1-1 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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