- Clone
- QA19A84 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Gamma-aminobutyric acid type B receptor subunit 2, gb2, GABA-BR2, GABA-B-R2, GABA-B receptor 2, GABA-B receptor, R2 subunit, G protein-coupled receptor 51, G-protein coupled receptor 51, gamma-aminobutyric acid B receptor 2, GABABR2, GABBR2
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
600251 | 25 µg | 104€ | ||||
600252 | 100 µg | 259€ |
Gamma-aminobutyric acid, B [GABAB] receptors are located in the midbrain and help facilitate inhibitory signaling in the central nervous system. GABAB receptors exist as heterodimers, comprising of two subunits: GABABR1 and GABABR2 with 7 transmembrane domains, neither of which is fully functional when expressed alone. The GABABR1 inhibits neurotransmitter activity via binding γ-aminobutyric acid (GABA), following G protein-coupled pathway activation through interacting with GABABR2. Subsequently, this signaling cascade changes ion channel activity and induces adenylyl cyclase to interfere synaptic responses. A decrease in GABABR2 functional efficacy is implicated in several diseases, such as Rett syndrome and epileptic encephalopathy.
Product DetailsProduct Details
- Verified Reactivity
- Rat, Mouse, Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Immunogen
- Partial recombinant mouse GABABR2 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by western blotting. For western blotting, the suggested use of this reagent is 0.25 - 1.0 µg/mL. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
It is recommended to boil cell or tissue lysates at 70°C for western blot.
Reactivity of clone QA19A84 with human GABABR2 is observed but is weaker than reactivity with mouse or rat GABABR2. - RRID
-
AB_2910469 (BioLegend Cat. No. 600251)
AB_2910469 (BioLegend Cat. No. 600252)
Antigen Details
- Structure
- GABABR2 is a 941 amino acid protein with a molecular mass of 106 kD.
- Distribution
-
Membrane
- Function
- Synaptic Transmission
- Interaction
- GABABR1
- Biology Area
- Cell Biology, Neuroscience, Synaptic Biology
- Antigen References
-
- Yoo Y, et al. 2017. Ann Neurol. 82:466-478.
- Duthey B, et al. 2002. J Biol Chem. 277:3236-41.
- Filippov A, et al. 2000. J Neurosci. 20:2867-74.
- Blein S, et al. 2000. Cell Mol Life Sci. 57:635-50.
- Gene ID
- 9568 View all products for this Gene ID
- UniProt
- View information about GABABR2 on UniProt.org
Other Formats
View All GABABR2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-GABABR2 Recombinant Antibody | QA19A84 | WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-GABABR2 Recombinant Antibody
Total tissue lysates (15 µg total protein) from rat brain (L...
Follow Us