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Purified anti-human CD159c (NKG2C) Antibody

Pricing & Availability
Clone
S19005E (See other available formats)
Regulatory Status
RUO
Other Names
Killer Cell Lectin Like Receptor C2, KLRC2, NK Cell Receptor C
Isotype
Mouse IgG1, κ
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publications
S19005E_PURE_CD159c_Antibody_042920.png
Human peripheral blood lymphocytes were stained with purified CD159c (NKG2C) (clone S19005E) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD3 Pacific Blue™.
  • S19005E_PURE_CD159c_Antibody_042920.png
    Human peripheral blood lymphocytes were stained with purified CD159c (NKG2C) (clone S19005E) (left) or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD3 Pacific Blue™.
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375002 100 µg 282€
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Description

CD159c, also known as NKG2C or KLRC2, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2C is an activating NK cell receptor and it is expressed as a heterodimer with CD94. In human, NKG2C/CD94 complex interacts HLA-E on target cells and delivers activating signals through immunoreceptor tyrosine-based activation motifs. 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human NKG2C/CD94-transfectants
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

S19005E does not crossreact with mouse CD159c.

RRID
AB_2888870 (BioLegend Cat. No. 375002)

Antigen Details

Structure
Type II transmembrane proteins of the C-type lectin superfamily
Distribution

NK cells, NKT cells, T cell subsets

Function
Activating NK cell receptor
Ligand/Receptor
HLA-E
Cell Type
Lymphocytes, NK cells, NKT cells, T cells
Biology Area
Immuno-Oncology, Immunology
Molecular Family
Immune Checkpoint Receptors
Antigen References
  1. Malisheni M, et al. 2017. Front Immunol. 8:863. 
  2. Sáez-Borderías A, et al. 2009. J Immunol, 182:829.
  3. Kamiya T, et al. 2019. J. Clin. Invest. 129:2094.
Gene ID
3822 View all products for this Gene ID
UniProt
View information about CD159c on UniProt.org
Go To Top Version: 1    Revision Date: 04/29/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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