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Purified anti-human CD204 Antibody

Pricing & Availability
Clone
7C9C20 (See other available formats)
Regulatory Status
RUO
Other Names
CD204, Macrophage scavenger receptor, MSR, MSR1, SRA
Isotype
Mouse IgG2a, κ
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Product Citations
publications
7C9C20_PURE_CD204_Antibody_FC_091916
Human peripheral blood monocytes were stimulated 6 days with GM-CSF and then stained with purified CD204 (clone 7C9C20, filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG-PE.
  • 7C9C20_PURE_CD204_Antibody_FC_091916
    Human peripheral blood monocytes were stimulated 6 days with GM-CSF and then stained with purified CD204 (clone 7C9C20, filled histogram) or purified mouse IgG2a, κ isotype control (open histogram), followed by anti-mouse IgG-PE.
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371902 100 µg 231€
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Description

CD204, also known as scavenger receptor A (SR-A) and the macrophage scavenger receptor (MSR), is one of the phagocytic pattern-recognition receptors (PRRs) expressed on macrophages and dendritic cells. CD204 was initially identified as a receptor mediating recognition and internalization of low-density lipoprotein (LDL) by macrophages and playing critical roles in atherogenesis. CD204 recognizes apoptotic cells, modified lipid proteins, and exogenous pathogen-associated molecular patterns (PAMPs), which results in the induction of innate immune and inflammatory responses. CD204 can act as a co-receptor for Toll-like receptors, such as TLR3, TLR4, or TLR9, to facilitate the expression of proinflammatory cytokines. CD204 has been implicated in several pathological processes such as Alzheimer’s disease, sepsis, ischemic injury, and coronary artery disease.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Recombinant extracellular domain of human CD204.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Farhadian SF, et al. 2022. JCI Insight. 7:. PubMed
  2. Yuan Y, et al. 2019. Cancer Med. 8:3811. PubMed
RRID
AB_2629756 (BioLegend Cat. No. 371902)

Antigen Details

Structure
Type II transmembraine protein, trimer, member of the scavenger receptor familly.
Distribution

Macrophages, dendritic cells, strong expression in microglia during Alzheimer's disease.

Function
Uptake of negatively charged molecules.
Antigen References

1. Kelley JL, et al. 2014. Crit. Rev. Immunol. 34:241.
2. Chen Y, et al. 2011. Blood. 118:390.
3. Yu X, et al. 2011. J. Biol. Chem. 286:18795.
4. Limmon GV, et al. 2008. FASEB J. 22:159.

Gene ID
4481 View all products for this Gene ID
UniProt
View information about CD204 on UniProt.org
Go To Top Version: 1    Revision Date: 09/22/2016

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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