- Clone
- JD3 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TNFRSF25, TRAMP, Apo-3, WSL-1, LARD, DDR3, TR3, TNFRSF12
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
307102 | 100 µg | 165€ |
DR3 is also known as TNFRSF25, Apo-3, WSL-1, TRAMP, LARD, DDR3, and TR3. It is a member of the TNF receptor family expressed at low level by monocytes and granulocytes. Interaction of DR3 with its ligand (TWEAK), activates the NF-κB pathway and induces apoptosis.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- human DR3-Ig fusion protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Additional reported applications (for the relevant formats) include: The JD3 antibody is useful for immunofluorescent staining and flow cytometric analysis of DR3/TRAMP receptor expression. For most successful immunofluorescent staining results, it may be important to maximize signal over background by using a relatively bright fluorochrome-antibody conjugate (Cat. No. 307106) or by using a high sensitivity, three-layer staining technique (e.g., including a biotinylated antibody (Cat. No. 307104) or biotinylated anti-mouse IgG second step (Cat. No. 405303), followed by SAv-PE (Cat. No. 405204)).
- Application References
-
- Nakayama M, et al. 2002. J. Immunol. 168:734.
- RRID
-
AB_314660 (BioLegend Cat. No. 307102)
Antigen Details
- Structure
- TNFR superfamily
- Distribution
-
Activated lymphocytes and thymocytes
- Function
- Lymphocyte homeostasis
- Ligand/Receptor
- Apo-3L, TWEAK
- Cell Type
- Lymphocytes, Thymocytes
- Biology Area
- Apoptosis/Tumor Suppressors/Cell Death, Cell Biology, Immunology
- Molecular Family
- Cytokine/Chemokine Receptors
- Antigen References
-
1. Nakayama M, et al. 2002. J. Immunol. 168:734.
2. Nakayama M, et al. 2000. J. Exp. Med. 192:1373. - Gene ID
- 8718 View all products for this Gene ID
- UniProt
- View information about DR3 on UniProt.org
Related FAQs
Other Formats
View All DR3 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Biotin anti-human DR3 (TRAMP) | JD3 | FC |
PE anti-human DR3 (TRAMP) | JD3 | FC |
Purified anti-human DR3 (TRAMP) | JD3 | FC |
TotalSeq™-C1057 anti-human DR3 (TRAMP) | JD3 | PG |
TotalSeq™-B1057 anti-human DR3 (TRAMP) Antibody | JD3 | PG |
TotalSeq™-A1057 anti-human DR3 (TRAMP) | JD3 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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