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Purified anti-human EMR3 Recombinant Antibody

Pricing & Availability
Clone
QA20A59 (See other available formats)
Regulatory Status
RUO
Other Names
Adhesion G protein-coupled receptor E3; EGF module-containing mucin-like hormone receptor 3
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA20A59_PURE_EMR3_RECOM_Antibody_111221
Human peripheral blood granulocytes were stained with purified anti-human EMR3 recombinant (clone QA20A59) (filled histogram) or purified mouse IgG1, κ isotype (open histogram), followed by goat anti-mouse IgG Alexa Fluor® 647.
  • QA20A59_PURE_EMR3_RECOM_Antibody_111221
    Human peripheral blood granulocytes were stained with purified anti-human EMR3 recombinant (clone QA20A59) (filled histogram) or purified mouse IgG1, κ isotype (open histogram), followed by goat anti-mouse IgG Alexa Fluor® 647.
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366102 100 µg 240€
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Description

EMR3 is a member of the EGF-7 transmembrane (TM7) adhesion GPCR family. It is predominantly expressed on granulocytes, neutrophils, monocytes, and macrophages, and at lower levels on mature myeloid cells and dendritic cells. EMR3 is absent on lymphocytes, hematopoietic stem cells and myeloid progenitors.

Studies suggest that the EMR3 molecule is upregulated during late stages of neutrophil differentiation and is a marker for terminally differentiated cells. EMR3 may play a role in myeloid-myeloid interactions during immune and inflammatory responses.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2904400 (BioLegend Cat. No. 366102)

Antigen Details

Structure
EGF-like domain, 7-transmembrane
Distribution

Granulocytes, neutrophils, monocytes, macrophages, dendritic cells

Function
Adhesion, myeloid-myeloid cell interaction
Cell Type
Dendritic cells, Granulocytes, Monocytes, Neutrophils
Biology Area
Adaptive Immunity, Cell Adhesion, Immunology, Innate Immunity
Molecular Family
Adhesion Molecules, GPCR
Antigen References
  1. Matmati M. et al. 2007, J Leukoc Biol. 81:440-8.
  2. Stacey M, et al. 2001. J Biol Chem. 276:18863-70.
Gene ID
84658 View all products for this Gene ID
UniProt
View information about EMR3 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 11/12/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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