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Purified anti-human GP6 Antibody

Pricing & Availability
Clone
HY101 (See other available formats)
Regulatory Status
RUO
Other Names
Platelet glycoprotein VI, GPVI
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
HY101_PURE_GP6_Antibody_080822
Human peripheral blood platelets were stained with anti-human CD41 APC and purified anti-human GP6 (clone HY101) (left) or with purified anti-mouse IgG1, κ isotype control (right), followed by PE goat anti-mouse IgG.
  • HY101_PURE_GP6_Antibody_080822
    Human peripheral blood platelets were stained with anti-human CD41 APC and purified anti-human GP6 (clone HY101) (left) or with purified anti-mouse IgG1, κ isotype control (right), followed by PE goat anti-mouse IgG.
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383802 100 µg 199€
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Description

Glycoprotein VI (GPVI) is a 37 kD type-I transmembrane glycoprotein of the immunoglobulin superfamily, primarily expressed on platelets and megakaryocytes. GPVI is a collagen receptor and is involved in collagen-induced platelet adhesion and activation. GPVI plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Glycoprotein VI transfected cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Agonist, WB - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References
  1. Chen, H, et al. 2001. J Biol chem. 277: 3011-3019. (FC, WB)
  2. van Dievoet, M, et al. 2022. Platelets. 1,17:1-4. (Agonist)
RRID
AB_2924586 (BioLegend Cat. No. 383802)

Antigen Details

Structure
Type-I transmembrane glycoprotein, 37 kD, member of the immunoglobulin superfamily,
Distribution

Megakaryocytes, Platelets

Function
Platelet adhesion and activation, blood coagulation, and hemostasis
Interaction
FcR gamma-chain, Src kinases, SYK, LAT
Ligand/Receptor
Collagen
Gene ID
51206 View all products for this Gene ID
UniProt
View information about GP6 on UniProt.org
Go To Top Version: 1    Revision Date: 08/08/2022

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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