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Purified anti-human GPR56 Antibody

Pricing & Availability
Clone
4C3 (See other available formats)
Regulatory Status
RUO
Other Names
TM7XN1
Isotype
Mouse IgG1, κ
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publications
4C3_PURE_GPR56_Antibody_1_052517
Human peripheral blood lymphocytes were stained with CD56 Pacific Blue™ and purified GPR56 (clone 4C3) (top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG1 FITC.
  • 4C3_PURE_GPR56_Antibody_1_052517
    Human peripheral blood lymphocytes were stained with CD56 Pacific Blue™ and purified GPR56 (clone 4C3) (top) or purified mouse IgG1, κ isotype control (bottom), followed by anti-mouse IgG1 FITC.
  • 4C3_PURE_GPR56_Antibody_2_052517
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391902 100 µg 231€
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Description

GPR56, also known as TM7XN1, is an orphan G-protein-coupled receptor (GPCR) containing seven transmembrane domains and a mucin-like domain in the N-terminal region. The total length of the human GPR56 gene is approximately 15 kb, and it consists of 13 exons and encodes 693 amino acids.  GPR56 is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. Mutations in human GPR56 gene were found to cause a specific brain malformation called bilateral frontoparietal polymicrogyria. Recently, GPR56 was found specifically expressed on cytotoxic NK and T lymphocytes, including CD8+, CD4+, and γδ T cells, which might affect the migratory properties of these cells. GPR56 was also found significantly downregulated in some cancer cells, suggesting that it may play a role in growth suppression and cancer metastasis.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human GPR56 extracellular domain, complete Freund’s adjuvant, incomplete Freund’s adjuvant
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Blocking, Direct ELISA, IP - Reported in the literature, not verified in house
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

Additional reported applications (for the relevant formats) include: blocking the cell migration (1).

Application References
  1. Ohta S, et al. 2015. Biol. Pharm. Bull. 38:594.
RRID
AB_2687290 (BioLegend Cat. No. 391902)

Antigen Details

Structure
Contains seven transmembrane domains and a mucin-like domain in the N-terminal region.
Distribution

T cells, NK cells, wide range of tissues such as brain, thyroid gland, and heart.

Function
May be involved in immune cell migration, cancer cell growth metastasis, and neuron development.
Cell Type
T cells, NK cells
Antigen References

1. Peng YM, et al. 2011. J. Leuko. Biol. 90:735.
2. Shashidhar S, et al. 2005. Oncogene 24:1673.
3. Piao X, et al. 2004. Science 303:2033.
4. Liu M, et al. 1999. Genomics 55:296.

Gene ID
9289 View all products for this Gene ID
UniProt
View information about GPR56 on UniProt.org
Go To Top Version: 0    Revision Date: 05/30/2017

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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