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Purified anti-human IL-1β Antibody

Pricing & Availability
Clone
H1b-27 (See other available formats)
Regulatory Status
RUO
Other Names
Interleukin-1β, H1, OAF, Catabolin, IFNb-inducing factor(il-1b,il1b)
Isotype
Mouse IgG2b, κ
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Product Citations
publications
Cat # Size Price Quantity Check Availability Save
511601 50 µg 85€
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511602 500 µg 226€
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Description

IL-1 refers to two proteins, IL-1α and IL-1β which are the products of distinct genes, but which are recognized by the same cell surface receptors. IL-1β is a potent immuno-modulator which mediates a wide range of immune and inflammatory responses including the activation of B and T cells. 

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

ELISA Capture - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by ELISA assay. Purified H1b-27 is useful as the capture antibody in a sandwich ELISA when used in conjunction with the biotinylated Poly5174 (Cat. No. 517403) or H1b-98 antibody (Cat. No. 511703). For ELISA capture applications, a concentration range of 2-6 µg/ml is recommended. It is recommended that the reagent be titrated for optimal performance for each application.

Product Citations
  1. Diray-Arce J, et al. 2023. Cell Rep Med. 4:101079. PubMed
  2. Huang C, et al. 2019. Cell Rep. 29:4525. PubMed
  3. Stras SF, et al. 2020. Developmental Cell. 51(3):357-373.e5.. PubMed
  4. Croden J, et al. 2021. PLoS One. 16:e0258208. PubMed
  5. Bando H, et al. 2019. Front Cell Infect Microbiol. 9:140. PubMed
  6. Watkins H, et al. 2017. Mol Ther. 10.1016/j.ymthe.2017.01.010. PubMed
  7. Stensland ZC, et al. 2022. iScience. 25:103626. PubMed
  8. Lavin Y et al. 2017. Cell. 169(4):750-765 . PubMed
RRID
AB_1236518 (BioLegend Cat. No. 511601)
AB_1236518 (BioLegend Cat. No. 511602)

Antigen Details

Structure
Cytokine; 17.3 kD
Bioactivity
Stimulates T cells, B cells, proliferation/activation of NK cells, fibroblasts, thymocytes, glioblastoma cells, astroglia, microglia
Cell Sources
Monocytes, tissue macrophages, Langerhans cells, dendritic cells, T and B cells, natural killer (NK) cells, large granular lymphocytes (LGL), vascular endothelium, smooth muscle, fibroblasts, thymic epithelia, astrocytes, microglia, glioma, keratinocytes,
Cell Targets
B cells, T cells, monocytes
Receptors
Type I IL-1R (CDw121a), Type II IL-1R (CDw121b)
Biology Area
Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family
Cytokines/Chemokines
Antigen References

1. Fitzgerald K, et al. Eds. 2001. The Cytokine FactsBook. Academic Press San Diego.
2. Bomford R, et al. Eds. 1989. Interleukin-1 inflammation and disease. Elsevier New York.
3. Brazel D, et al. 1991. Biotechnol. Ther. 2:241.
4. Dinarello C. 1996. Blood 87:2095.

Regulation
Upregulated by TNF-α, IFN-α, IFN-β, IFN-γ, bacterial endotoxins, viruses, mitogens, antigens; downregulated by IL-6, lipoproteins, lipids, and α2-macroglobulin
Gene ID
3553 View all products for this Gene ID
UniProt
View information about IL-1beta on UniProt.org

Other Formats

View All IL-1β Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-human IL-1β H1b-27 ELISA Capture
Ultra-LEAF™ Purified anti-human IL-1β H1b-27 ELISA Capture,ELISPOT Capture
Go To Top Version: 2    Revision Date: 09/13/2013

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

BioLegend, the BioLegend logo, and all other trademarks are property of BioLegend, Inc. or their respective owners, and all rights are reserved.

 

8999 BioLegend Way, San Diego, CA 92121 www.biolegend.com
Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

  • Purified anti-human IL-1β

  • Ultra-LEAF™ Purified anti-human IL-1β

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