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Purified anti-mouse CD338 (ABCG2) Antibody

Pricing & Availability
Clone
S17006D (See other available formats)
Regulatory Status
RUO
Other Names
ABCG2, CDw338, Bcrp1, MXR, ABCP, MRX, BMDP
Isotype
Rat IgG2b, κ
Ave. Rating
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Product Citations
publications
S17006D_PURE_CD338_Antibody_1_113021
C57BL/6 bone marrow cells were stained with anti-mouse TER-119 APC and purified anti-mouse CD338 (ABCG) (clone S17006D) (left) or purified rat IgG2b, κ (right), followed by anti-rat IgG PE. Data shown was gated cells that were negative for anti-mouse CD45.
  • S17006D_PURE_CD338_Antibody_1_113021
    C57BL/6 bone marrow cells were stained with anti-mouse TER-119 APC and purified anti-mouse CD338 (ABCG) (clone S17006D) (left) or purified rat IgG2b, κ (right), followed by anti-rat IgG PE. Data shown was gated cells that were negative for anti-mouse CD45.
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164302 100 µg 123€
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Description

CD338, also known as ABCG2 or BCRP1, is a 72 kD multi-drug resistance (MDR) protein member of ATP binding cassette (ABC) transporters. CD338 is expressed on stem cells from a variety of tissues and in many cancer types where it contributes to their resistance to chemotherapeutic drugs. ABCG2 is also up-regulated during erythroid differentiation. The expression of ABCG2 appears to be highly conserved as it has been identified in various species.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Rat
Immunogen
mAbcg2-transfectants/ epitope is listed as extracellular domain
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality Tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

RRID
AB_2924495 (BioLegend Cat. No. 164302)

Antigen Details

Structure
Member of the G subfamily of human ATP-binding cassette (ABC) transporter superfamily
Distribution

Stem cells from multiple lineages, erythroid cells, cancerous cells

Function
Acts as a xenobiotic efflux transport protein that can transport chemotherapeutic drugs (making them resistant to the chemotherapy)
Antigen References
  1. Hoque KM, et al. 2020. Nat Commun. 11:2767.
  2. Jonker JW, et al. 2005. Nat Med. 11:127-9.
  3. Zhou E, et al. 2005. Blood. 105:2571-6.
  4. Kina T, et al. 2000. Br J Haem. 109:280-7.

 

Gene ID
26357 View all products for this Gene ID
UniProt
View information about CD338 on UniProt.org
Go To Top Version: 1    Revision Date: 11/29/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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