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- Clone
- S17006D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- ABCG2, CDw338, Bcrp1, MXR, ABCP, MRX, BMDP
- Isotype
- Rat IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 bone marrow cells were stained with anti-mouse TER-119 APC and purified anti-mouse CD338 (ABCG) (clone S17006D) (left) or purified rat IgG2b, κ (right), followed by anti-rat IgG PE. Data shown was gated cells that were negative for anti-mouse CD45.
| Cat # | Size | Price | Quantity Check Availability | Save | ||
|---|---|---|---|---|---|---|
| 164302 | 100 µg | 123€ | ||||
CD338, also known as ABCG2 or BCRP1, is a 72 kD multi-drug resistance (MDR) protein member of ATP binding cassette (ABC) transporters. CD338 is expressed on stem cells from a variety of tissues and in many cancer types where it contributes to their resistance to chemotherapeutic drugs. ABCG2 is also up-regulated during erythroid differentiation. The expression of ABCG2 appears to be highly conserved as it has been identified in various species.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- mAbcg2-transfectants/ epitope is listed as extracellular domain
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality Tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2924495 (BioLegend Cat. No. 164302)
Antigen Details
- Structure
- Member of the G subfamily of human ATP-binding cassette (ABC) transporter superfamily
- Distribution
-
Stem cells from multiple lineages, erythroid cells, cancerous cells
- Function
- Acts as a xenobiotic efflux transport protein that can transport chemotherapeutic drugs (making them resistant to the chemotherapy)
- Antigen References
-
- Hoque KM, et al. 2020. Nat Commun. 11:2767.
- Jonker JW, et al. 2005. Nat Med. 11:127-9.
- Zhou E, et al. 2005. Blood. 105:2571-6.
- Kina T, et al. 2000. Br J Haem. 109:280-7.
- Gene ID
- 26357 View all products for this Gene ID
- UniProt
- View information about CD338 on UniProt.org
Related FAQs
Other Formats
View All CD338 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-mouse CD338 (ABCG2) | S17006D | FC |
| APC anti-mouse CD338 (ABCG2) | S17006D | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-mouse CD338 (ABCG2)
C57BL/6 bone marrow cells were stained with anti-mouse TER-1... -
APC anti-mouse CD338 (ABCG2)
C57BL/6 bone marrow cells were stained with anti-mouse TER-1...
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