- Clone
- 4A9 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- IL-21 Receptor
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Quantity Check Availability | Save | ||
---|---|---|---|---|---|---|
131902 | 500 µg | 282€ |
The IL-21R is a member of the cytokine receptor family that closely resembles IL-2R beta and IL-4R alpha. IL-21R is expressed by all mature lymphocytes and up-regulated after B and/or T cell activation, with the highest expression by activated B cells. A functional IL-21R consists of the IL-21R subunit and the commone gamma-chaiin. Upon binding to IL-21, it activates Jak-1, Jak-3, STAT1, STAT3 and STAT 5 transduction pathway.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Rat YB2/0 hybridoma transfectant cell line expressing truncated IL-21R
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
IP - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application References
-
- Jin H, et al. 2004. J. Immunol. 173:657. (FC)
- Jin H and Malek T. 2006. J. Leukocyte Biol. 80:1416. (FC IP)
- Product Citations
-
- RRID
-
AB_1279435 (BioLegend Cat. No. 131902)
Antigen Details
- Structure
- A member of the class 1 cytokine receptor family. Show significant sequence and structural homology with the IL-4R alpha chain.
- Distribution
-
Express on all mature lymphocytes including B cells, T cells, and NK cells. Reported to be up-regulated upon activation and highest expression on follicular B cells.
- Ligand/Receptor
- IL-21
- Cell Type
- B cells, Lymphocytes
- Biology Area
- Immunology
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
1.Mehta DS, et al. 2004. Immu Reviews 202:84
- Gene ID
- 60504 View all products for this Gene ID
- UniProt
- View information about IL-21R on UniProt.org
Related FAQs
Other Formats
View All IL-21R Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-mouse IL-21R | 4A9 | FC,IP |
PE anti-mouse IL-21R | 4A9 | FC |
PE/Cyanine5 anti-mouse IL-21R | 4A9 | FC |
APC anti-mouse IL-21R | 4A9 | FC |
TotalSeq™-C0879 anti-mouse IL-21R | 4A9 | PG |
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