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Purified anti-Pax-6 Antibody (Previously Covance catalog# PRB-278P)

Pricing & Availability
Clone
Poly19013 (See other available formats)
Regulatory Status
RUO
Other Names
Paired box protein Pax-6, oculorhombin, aniridia type II protein, Sey, Protein eyeless, PRB-278P-100
Previously
Covance Catalog# PRB-278P
Isotype
Rabbit Polyclonal IgG
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Product Citations
publications
1-Poly19013_PURE_Pax-6_Antibody_1_091420
Whole cell extracts (15µg total protein) from 293T (human), (left panel) or E17 Ms. brain (mouse brain at day 17 of development), (right panel) were resolved by 4-12% Bis-Tris gel electrophoresis, transferred to PVDF membrane and probed with 1.0 µg/mL (1:2000 dilution) of purified Pax-6 rabbit antibody (clone Poly19013) for 2 hr at RT. Proteins were visualized by chemiluminescence detection using HRP Donkey anti-rabbit IgG Antibody (Cat. No. 406401, 1:3000 dilution). Direct-Blot™ HRP anti-GAPDH antibody (Cat. No. 607904) was used as a loading control at 1:25000 dilution (lower). Lane M:Molecular weight marker.
  • 1-Poly19013_PURE_Pax-6_Antibody_1_091420
    Whole cell extracts (15µg total protein) from 293T (human), (left panel) or E17 Ms. brain (mouse brain at day 17 of development), (right panel) were resolved by 4-12% Bis-Tris gel electrophoresis, transferred to PVDF membrane and probed with 1.0 µg/mL (1:2000 dilution) of purified Pax-6 rabbit antibody (clone Poly19013) for 2 hr at RT. Proteins were visualized by chemiluminescence detection using HRP Donkey anti-rabbit IgG Antibody (Cat. No. 406401, 1:3000 dilution). Direct-Blot™ HRP anti-GAPDH antibody (Cat. No. 607904) was used as a loading control at 1:25000 dilution (lower). Lane M:Molecular weight marker.
  • 2-Poly19013_PURE_Pax-6_Antibody_2_091420
    Whole cell extracts (15 µg total protein) from either untransfected 293E cells or transfected with GFP were resolved by 4-12% Bis-Tris gel electrophoresis, transferred to PVDF membrane and probed with 1.0 µg/mL (1:2000 dilution) of purified Pax-6 rabbit antibody (clone Poly19013) (panel A) or purified anti-GFP antibody (clone 1GFP63, Cat. No. 668206) for 2 hr at RT. Proteins were visualized by chemiluminescence detection using HRP Donkey anti-rabbit IgG Antibody (Cat. No. 406401, 1:3000 dilution) or HRP Goat anti-mouse IgG Antibody (Cat. No. 405306, 1:3000 dilution). Direct-Blot™ HRP anti-GAPDH antibody (Cat. No. 607904) was used as a loading control at 1:25000 dilution (lower).Lane M:Molecular weight marker.
  • 3_Purified_Pax-6_Antibody_IHC_2_021315
    IHC staining of purified anti-Pax-6 antibody (clone Poly19013) on formalin-fixed paraffin-embedded mouse brain tissue. Following antigen retrieval using Sodium Citrate H.I.E.R., the tissue was incubated with 20 µg/ml of the primary antibody for 60 minutes at room temperature. BioLegend's Ultra-Streptavidin (USA) HRP kit (Multi-Species, DAB, Cat. No. 929901) was used for detection followed by hematoxylin counterstaining, according to the protocol provided. The image was captured with a 40X objective.
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901302 25 µL 109€
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901301 100 µL 331€
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Description

Pax6 is a transcription factor present during embryonic development. The encoded protein contains two different binding sites that are known to bind DNA and function as a regulator of gene transcription. It is a key regulatory gene of eye and brain development. Within the brain, the protein is involved in development of specialized cells that process smell. Pax-6 acts as a critical gene for the development of eyes and other sensory organs, certain neural and epidermal tissues as well as other homologous structures, usually derived from ectodermal tissues. Pax6 serves as a regulator in the coordination and pattern formation required for differentiation and proliferation to successfully take place, ensuring that the processes of neurogenesis and oculogenesis are carried out successfully. As a transcription factor, Pax6 acts at the molecular level in the signaling and formation of the central nervous system. The characteristic paired DNA binding domain of Pax6 utilizes two DNA-binding domains, the paired domain (PD), and the paired-type homeodomain (HD). These domains function separately. An example of this lies in HD’s regulatory involvement in the formation of the lens and retina throughout oculogenesis contrasted by the molecular mechanisms of control exhibited on the patterns of neurogenesis in brain development by PD. The HD and PD domains act in close coordination, giving Pax6 its multifunctional nature in directing molecular signaling in formation of the CNS.

The vertebrate PAX6 locus encodes at least three different protein isoforms, these being the canonical PAX6, PAX6(5a), and PAX6(ΔPD). The canonical PAX6 protein contains an N-terminal paired domain, connected by a linker region to a paired-type homeodomain, and a proline/serine/threonine (P/S/T)-rich C-terminal domain. The paired domain and paired-type homeodomain each have DNA binding activities, while the P/S/T-rich domain possesses a transactivation function. PAX6(5a) is a product of the alternatively spliced exon 5a resulting in a 14 residue insertion in the paired domain which alters the specificity of this DNA binding activity. The nucleotide sequence corresponding to the linker region encodes a set of three alternative translation start codons from which the third PAX6 isoform originates. Collectively known as the PAX6(ΔPD) or pairedless isoforms, these three gene products all lack a paired domain. The pairedless proteins possess molecular weights of 43, 33, or 32kDa, depending on the particular start codon used. PAX6 transactivation function is attributed to the variable length C-terminal P/S/T-rich domain which stretches to 153 residues in human and mouse proteins.

Product Details
Technical Data Sheet (pdf)

Product Details

Verified Reactivity
Human, Mouse, Rat
Antibody Type
Polyclonal
Host Species
Rabbit
Immunogen
This antibody was generated against the peptide (QVPGSEPDMSQYWPRLQ) derived from the C-terminus of the mouse Pax-6 protein.
Formulation
Phosphate-buffered solution + 0.03% Thimerosal.
Preparation
The antibody was purified by affinity chromatography.
Concentration
2 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C. Please note the storage condition for this antibody has been changed from -20°C to between 2°C and 8°C. You can also check your vial or your CoA to find the most accurate storage condition for this antibody.
Application

WB, IHC-P - Quality tested
IHC-F - Reported in the literature, not verified in house

Recommended Usage

Each lot of this antibody is quality control tested by Western blotting and formalin-fixed paraffin-embedded immunohistochemical staining of brain tissue. For Western blotting, the suggested use of this reagent is 1.0 µg/mL (1:2000). For immunohistochemistry, a dilution of 1:50 - 1:100 is suggested. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

This antibody weakly reacts with rat. It has also shown reactivity with GFP and is therefore not recommended for use in GFP-expressing systems (as determined by in-house testing).

Pax-6 has two isoforms in human and mice at 46.6 and 48.2 Kd. This antibody recognizes both. The sequence is highly conserved among Pax-6 of various species. The antibody was subsequently purified on a Protein A column and is useful in studying brain, neuronal and olfactory development in higher eukaryotes.

This clone is not recommended for ChIP (Chromatin Immunoprecipitation) assays (as determined by in-house testing).

Application References
  1. Tang K, et al. 2012. Development. 139:1630. (IF) PubMed
  2. Bandah D, et al. 2007. Invest. Ophthalmol. Vis. Sci. 48:2503. (WB) PubMed
  3. Marquardt T, et al. 2001. Cell. 105:43.
  4. Yamamoto Y, Jeffery WR. 2000. Science. 289:631
  5. Ashery-Padan R, et al. 2000. Genes Dev. 14:2701.
  6. Osumi N, et al. 1997. Development. 124:2961.
  7. Koroma BM, et al. 1997. Invest. Ophthalmol Vis Sci. 38:108.
  8. Davis JA, Reed RR. 1996. J Neurosci. 16:5082. (IHC)
  9. Quadrato G, et al. Nature. 545:48. (IF) PubMed
Product Citations
  1. Ahmad Z, et al. 2015. PLoS One. 10: 0144597. PubMed
  2. Ramzy A, et al. 2018. Endocrinology. 159:83. PubMed
  3. Scior A, et al. 2018. EMBO J. 37:282. PubMed
  4. Wilson CS, et al. 2019. JCI Insight. 5. PubMed
  5. Nazir FH, et al. 2018. Neurochem Int. 121:38. PubMed
  6. Bashford AL, et al. 2019. J Pathol. 248:396. PubMed
  7. Del Toro D et al. 2017. Cell. 169(4):621-635 . PubMed
  8. Popova G, et al. 2021. Cell Stem Cell. 28:2153. PubMed
  9. Muralidharan H, et al. 2022. J Neurosci. 42:2149. PubMed
  10. Jabali A, et al. 2022. EMBO Rep. 23:e54027. PubMed
  11. Jia X, et al. 2022. Sci Adv. 8:eabo7112. PubMed
  12. Chen X, et al. 2023. Neuron. 111:30. PubMed
  13. Sterling NA, et al. 2023. Nat Commun. 14:82. PubMed
  14. Kokorudz C, et al. 2022. Cells. 12: . PubMed
  15. Zhong Z, et al. 2022. Bio Protoc. 12: . PubMed
  16. Xue W, et al. 2023. iScience. 26:105898. PubMed
  17. Cheng Q, et al. 2023. Mol Brain. 16:24. PubMed
  18. Zhong DJ, et al. 2021. FASEB J. 35:e21842. PubMed
  19. Le Floch P, et al. 2022. Adv Mater. 34:e2106829. PubMed
  20. Lorenz C, et al. 2022. Stem Cell Res. 61:102742. PubMed
  21. Brozko N, et al. 2022. Front Neuroanat. 16:838567. PubMed
  22. Gallo RA, et al. 2022. Transl Vis Sci Technol. 11:4. PubMed
  23. Habib K, et al. 2022. Mol Cells. 45:588. PubMed
  24. Wang S, et al. 2022. J Neurosci. 42:7031. PubMed
  25. Tarazi S, et al. 2022. Cell. 185:3290. PubMed
  26. Wang L, et al. 2022. Proc Natl Acad Sci U S A. 119:e2206147119. PubMed
  27. , et al. 2022. Nature. 609:1021. PubMed
  28. Whye D, et al. 2023. Curr Protoc. 3:e641. PubMed
  29. Dong Z, et al. 2023. J Biol Chem. 299:103020. PubMed
  30. Loan A, et al. 2023. iScience. 26:106093. PubMed
  31. Li B, et al. 2023. Cell Discov. 9:27. PubMed
  32. Guo CJ, et al. 2023. Mol Ther Nucleic Acids. 31:763. PubMed
  33. Xu A, et al. 2023. Nat Commun. 14:1694. PubMed
  34. Eigenhuis KN, et al. 2023. Front Cell Neurosci. 17:1114420. PubMed
  35. Cappuccio G, et al. 2023. Front Mol Biosci. 10:1181965. PubMed
  36. Rybak-Wolf A, et al. 2023. Nat Microbiol. . PubMed
  37. Ziffra RS, et al. 2021. Nature. 598:205. PubMed
  38. Schroeter MS, et al. 2022. MRS Bull. 47:530. PubMed
  39. Subramanian L, et al. 2017. Nat Commun. 8:14167. PubMed
  40. Schmid B, et al. 2021. Stem Cell Research. 52:102180. PubMed
  41. Ma L, et al. 2021. Stem Cell Research. 53:102305. PubMed
  42. Li J, et al. 2021. Stem Cell Research. 53:102376. PubMed
  43. Martens YA, et al. 2021. STAR Protocols. 2(2):100571. PubMed
  44. Hwang SH, et al. 2021. eLife. 0.416666666666667. PubMed
  45. Tristan CA, et al. 2020. bioRxiv. . PubMed
  46. Takahashi K, et al. 2021. PLoS Genet. 17:e1009587. PubMed
  47. Tian E, et al. 2016. Cell Rep. 16: 781-792. PubMed
  48. Small K, et al. 2015. Ophthalmology. 13: 681-685. PubMed
  49. Bershteyn M, et al. 2017. Cell Stem Cell. 20:435. PubMed
  50. Panagiotakos G, et al. 2019. Elife. 8:e51037. PubMed
  51. Peter CJ, et al. 2019. Nat Commun. 10:4112. PubMed
  52. Bovio PP, et al. 2019. Mol Neurobiol. 56:4273. PubMed
  53. Ing-Esteves S, et al. 2018. J Neurosci. 38:2713. PubMed
  54. Viais R, et al. 2021. Elife. 10:. PubMed
  55. Avilés EC, et al. 2022. Cell Rep. 38:110307. PubMed
  56. Notaras M, et al. 2021. Mol Psychiatry. Online ahead of print. PubMed
  57. Taniguchi-Ikeda M, et al. 2021. iScience. 24:103140. PubMed
  58. Merkert S, et al. 2021. Stem Cell Research. 52:102208. PubMed
  59. Gao X, et al. 2020. Stem Cell Research. 48:101986. PubMed
  60. Patmore DM, et al. 2020. Developmental Cell. 54(4):455-470.e5. PubMed
  61. Moura D, et al. 2016. Sci Rep. 6:28532. PubMed
  62. Bonnefont J, et al. 2019. Neuron. 103:1096. PubMed
  63. Hickmott JW, et al. 2018. Gene Ther. 25:524. PubMed
  64. Liu J et al. 2017. Cell stem cell. 21(5):635-649 . PubMed
  65. Junqueira Alves C, et al. 2021. Nat Commun. 12:6019. PubMed
  66. Sun X, et al. 2021. Stem Cell Research. 52:102230. PubMed
  67. Kafarnik C, et al. 2020. Stem Cells Dev. 425:29. PubMed
  68. Sood S, et al. 2020. Proc Natl Acad Sci U S A. 22331:117. PubMed
  69. Singer RA, et al. 2020. Cell Metabolism. 30(6):1091-1106. PubMed
  70. Saito K, et al. 2019. Cell Rep. 29:1555. PubMed
  71. Girskis KM, et al. 2021. Neuron. 109:3239. PubMed
  72. Liu X, et al. 2021. Cell Prolif. 54:e13124. PubMed
  73. Kalusa M, et al. 2021. Front Neuroanat. 15:678385. PubMed
  74. Gregory JA, et al. 2020. Cells. 9:00. PubMed
  75. de Leeuw VC, et al. 2020. Cell Reprogram. 1.125. PubMed
  76. Ucuncu E, et al. 2020. Nat Commun. 4.685416667. PubMed
  77. Bandah D, et al. 2007. Invest Ophthalmol Vis Sci. 48:2503-2509. PubMed
  78. Pataskar A, et al. 2016. EMBO J. 35: 24 - 45. PubMed
  79. Broix L, et al. 2016. Nat Genet. 48:1349-1358. PubMed
  80. Chen Y, et al. 2019. Methods Mol Biol. 1919:59:00. PubMed
  81. Moore D, et al. 2019. Stem Cells Int. 2019:8710180. PubMed
  82. Komabayashi-Suzuki M, et al. 2019. Cell Rep. 29:1113. PubMed
  83. Selvadurai HJ, et al. 2020. Cell Reports. 31(2):107511.. PubMed
  84. Shao W, et al. 2020. Nature. 580:106. PubMed
  85. Janssens S, et al. 2018. mSystems. 3. PubMed
  86. Tripathy R, et al. 2018. Neuron. 100:1354. PubMed
  87. Wang H, et al. 2019. Cell Rep. 27:2335. PubMed
  88. Tristan CA, et al. 2022. Nat Protoc. Online ahead of print. PubMed
  89. LaForce GR, et al. 2022. Neuron. 110:1340. PubMed
  90. Slot E, et al. 2020. Stem Cell Res. 101745:44. PubMed
  91. Sun WR, et al. 2020. Hum Mol Genet. . PubMed
  92. Freude KK, et al. 2020. World J Stem Cells. 1171:12. PubMed
  93. Taverna E, et al. 2016. Sci Rep. 6:21206. PubMed
  94. Ezan J, et al. 2021. Sci Rep. 9106:11. PubMed
  95. Nakashima H, et al. 2021. Cell Reports. 35(7):109124. PubMed
  96. Lardelli R, et al. 2017. Nat Genet. 10.1038/ng.3762. PubMed
  97. Delépine C, et al. 2016. Hum Mol Genet. 25: 146 - 157. PubMed
  98. Xu J, et al. 2016. Sci Transl Med. 8: 333ra48. PubMed
  99. Bonney S, et al. 2016. J Neurosci. 36: 7786 - 7801. PubMed
  100. Pei S, et al. 2016. Sci Rep. 6:33822. PubMed
  101. M Rodriguez, S Noctor, E Muñoz 2016. PLoS One. 11:e0167063. PubMed
  102. Boland M, et al. 2017. Brain. 10.1093/brain/aww357. PubMed
  103. Matsumura K, et al. 2020. Nat Commun. 11:859. PubMed
  104. Lee EJ, et al. 2020. Cell Reports. 28(3):712-722.e3.. PubMed
  105. Roy A, et al. 2020. Acta Neuropathologica Communications. 8(1):54.. PubMed
  106. Shafa M, et al. 2018. Front Med (Lausanne). 9:1816. PubMed
  107. Zhang X, et al. 2019. Protein Cell. 10:649. PubMed
  108. Postel M, et al. 2019. BMC Bioinformatics. 20:470. PubMed
  109. Ma L, et al. 2022. iScience. 25:105172. PubMed
  110. Li M, et al. 2021. Nat Commun. 12:420. PubMed
  111. Craenen K, et al. 2020. Reprod Toxicol. 91:59. PubMed
  112. Walker H, et al. 2021. Int J Mol Sci. 22:. PubMed
  113. Hou S, et al. 2021. Cereb Cortex. 31:4730. PubMed
  114. Ahn LY, et al. 2021. J Neurosci Res. 99:110. PubMed
  115. Birkhoff JC, et al. 2020. Hum Mol Genet. 29:2535. PubMed
  116. Pereiro X, et al. 2020. Cells. 9:00. PubMed
  117. Kim TW, et al. 2021. Cell Stem Cell. 28(2):343-355.e5. PubMed
  118. Simsa R, et al. 2021. PLoS One. 16:e0245685. PubMed
  119. Retallack H, et al. 2016. Proc Natl Acad Sci U S A. 113(50):14408-14413. PubMed
  120. Simonin Y, et al. 2016. EBioMedicine. 12:161-169. PubMed
  121. Otani T, et al. 2016. Cell Stem Cell. 18: 467-480. PubMed
  122. Tomita H, et al. 2020. Cell Reports. 30(1):215-228.e5.. PubMed
  123. Plaza Reyes A, et al. 2020. Nat Commun. 11:1609. PubMed
  124. Wang Q, et al. 2017. Curr Biol. 27:1791. PubMed
  125. Todd L, et al. 2017. Glia. 65:1640. PubMed
  126. Lu HC, et al. 2017. Nat Genet. 49:527. PubMed
  127. Dhumale P, et al. 2018. PLoS One. 9:1544. PubMed
  128. Chen X, et al. 2022. PLoS Biol. 20:e3001868. PubMed
  129. Li N, et al. 2021. Stem Cell Research. 53:102322. PubMed
  130. Gao X, et al. 2021. Stem Cell Research. 53:102271. PubMed
  131. Schinzel F, et al. 2021. Journal of Comparative Neurology. 529(11):3032-3045. PubMed
  132. Xiao D, et al. 2020. Sci Adv. 6:eaaz5858. PubMed
  133. Harkin L, et al. 2016. Cereb Cortex. 10.1093/cercor/bhw394. PubMed
  134. Fregeac J, et al. 2020. Mol Autism. 11:22. PubMed
  135. Li L, et al. 2019. Cell Rep. 28:698. PubMed
  136. Omer Javed A, et al. 2018. Cell Rep. 25:368. PubMed
  137. Sun D, et al. 2017. PLoS One. 12(6):e0179047. PubMed
  138. Chau KF, et al. 2018. Elife. 19:E663. PubMed
  139. Andres LM, et al. 2017. ACS Chem Biol. 12:2030. PubMed
  140. Ibañez Rodriguez MP et al. 2018. The Journal of comparative neurology. 526(15):2462-2481 . PubMed
  141. Pollen AA, et al. 2019. Cell. 176:743. PubMed
  142. Cliff TS et al. 2017. Cell stem cell. 21(4):502-516 . PubMed
  143. Marczenke M, et al. 2021. Development. 148:. PubMed
  144. Zhu X, et al. 2022. Sci Adv. 8:eabl7263. PubMed
  145. Bosze B, et al. 2020. J Neurosci. 40:1501. PubMed
  146. Eze UC, et al. 2021. Nature Neuroscience. 24(4):584-594. PubMed
  147. Chen M, et al. 2021. Stem Cell Research. 51:102166. PubMed
  148. Breuss M, et al. 2017. Hum Mol Genet. 10.1093/hmg/ddw383. PubMed
  149. Paquet D, et al. 2016. Nature. 533: 125-129. PubMed
  150. Ramme AP, et al. 2020. Stem Cell Research. 41:101615.. PubMed
  151. Popovitchenko T, et al. 2020. Nat Commun. 11:1674. PubMed
  152. Velasco S, et al. 2019. Nature. 570:523. PubMed
  153. Forrest MP, et al. 2017. Cell Stem Cell. 1.086805556. PubMed
  154. Lavado A et al. 2018. Dev Cell. 47(5):576-591 . PubMed
  155. Docampo–Seara A, et al. 2018. Brain Struct Funct. 223:3593. PubMed
  156. Langer LF, et al. 2019. Elife. 8. PubMed
  157. Hoshino A, et al. 2017. Dev Cell. 43:763. PubMed
  158. Luisier R, et al. 2018. Nat Commun. 8:6458. PubMed
  159. Haldipur P, et al. 2021. Acta Neuropathol. 142:761. PubMed
  160. Li J, et al. 2021. Neural Plast. 2021:4894881. PubMed
  161. Schembs L, et al. 2022. Cell Rep. 39:110811. PubMed
  162. Soubannier V, et al. 2022. Cells. 11:. PubMed
  163. Manos JD, et al. 2022. iScience. 25:103658. PubMed
  164. Han X, et al. 2021. J Neurosci. Online ahead of print. PubMed
  165. Urciuolo A, et al. 2020. Nat Biomed Eng. 4:901. PubMed
  166. Ramme AP, et al. 2021. Stem Cell Research. 53:102327. PubMed
  167. Zhang L, et al. 2020. Cell Stem Cell. 27(5):784-797.e11. PubMed
  168. Jeong D, et al. 2020. Cell Rep. 33:108257. PubMed
  169. Okamoto M, et al. 2016. Nat Commun. 7: 11349. PubMed
  170. Hickmott J, et al. 2016. Mol Ther Methods Clin Dev. 3:16051. PubMed
  171. Zhu L, et al. 2016. J Cell Biol. 215: 187 - 202. PubMed
  172. Wörsdörfer P, et al. 2019. Sci Rep. 9:15663. PubMed
  173. Pandey PR, et al. 2019. Int J Mol Sci. 0.936805556. PubMed
  174. Mirjalili Mohanna SZ, et al. 2020. Mol Ther Methods Clin Dev. 17:478. PubMed
  175. Yin WC, et al. 2019. Dev Cell. 48:167. PubMed
  176. Goodson NB, et al. 2018. Dev Biol. 434:149. PubMed
  177. Ren X, et al. 2019. Cell Rep. 26:3643. PubMed
  178. Beattie R et al. 2017. Neuron. 94(3):517-533 . PubMed
  179. Parween S, et al. 2018. Front Cell Neurosci. 0.746527778. PubMed
  180. Chui A, et al. 2020. Development. . PubMed
  181. Chao J, et al. 2022. iScience. 25:104391. PubMed
  182. Ren R, et al. 2017. Cell Res. 10.1038/cr.2017.18. PubMed
  183. Ao Z, et al. 2020. Anal Chem. 4630:92. PubMed
  184. Li YP, et al. 2021. STAR Protoc. 2:100438. PubMed
  185. Clark AE, et al. 2020. J Virol. 95:e02024. PubMed
  186. Gey M, et al. 2016. J Neurosci. 36: 9057 - 9069. PubMed
  187. Sancho-Martinez I, et al. 2016. Nat Commun. 7:10743. PubMed
  188. Shu P, et al. 2019. J Biol Chem. 294:3444. PubMed
  189. Mao X, et al. 2019. Stem Cell Reports. 13:747. PubMed
  190. Lindsay CD, et al. 2019. Acta Biomater. 95:225. PubMed
  191. Shafa M, et al. 2019. Int J Mol Sci. 0.95. PubMed
  192. Gabriel E et al. 2017. Cell stem cell. 20(3):397-406 . PubMed
  193. Homman‐Ludiye J et al. 2018. The Journal of comparative neurology. 526(17):2870-2883 . PubMed
  194. Xu D, et al. 2018. PLoS Biol. 16:e2006613. PubMed
  195. Zahr SK et al. 2018. Neuron. 97(3):520-537 . PubMed
  196. Kim YJ, et al. 2018. Neuron. 100:1180. PubMed
  197. Tu J et al. 2018. Stem cell research. 28:29-32 . PubMed
  198. Mills T, et al. 2017. PLoS One.. 10.1371/journal.pone.0176905. PubMed
  199. Padmanabhan Nair V, et al. 2021. Cell Stem Cell. . PubMed
  200. Chui A, et al. 2020. Development. 147:00:00. PubMed
  201. Quintana-Urzainqui I, et al. 2020. Development. 147:00:00. PubMed
  202. Garreta E, et al. 2016. Biomaterials. 98:64-78. PubMed
  203. Robson JP, et al. 2019. PLoS One. 14:e0210665. PubMed
  204. Remez LA, et al. 2017. Dev Biol. 432:140. PubMed
  205. Klein T et al. 2019. Stem cell research. 1724:56:00 . PubMed
  206. Sano N et al. 2017. Frontiers in cellular neuroscience. 0.54375 . PubMed
  207. Kaufman ML, et al. 2021. Development. . PubMed
  208. Romero DM, et al. 2022. Nat Commun. 13:2746. PubMed
  209. Fischer M, et al. 2021. Alcohol Clin Exp Res. 45:979. PubMed
  210. Prince LM, et al. 2021. Food Chem Toxicol. 152:112178. PubMed
  211. Behesti H, et al. 2021. Elife. 10:. PubMed
  212. Kim HM, et al. 2020. Cell Prolif. :e12965. PubMed
  213. Usman A, et al. 2021. Stem Cell Research. 55:102488. PubMed
  214. Tachibana N, et al. 2016. J Neurosci. 36: 9454 - 9471. PubMed
  215. Lin H, et al. 2016. Nature. 531:323-328. PubMed
  216. Wang W, et al. 2016. Nat Commun. 7:10936. PubMed
  217. Bando Y, et al. 2016. Cereb Cortex. 26: 106 - 117. PubMed
  218. Cheng S, et al. 2019. J Neurosci. 39:2195. PubMed
  219. Uzquiano A, et al. 2019. Cell Rep. 28:1596. PubMed
  220. Docampo–Seara A, et al. 2019. Brain Struct Funct. 224:2325. PubMed
  221. Lim Y, et al. 2019. Sci Rep. 9:226. PubMed
  222. Nakano Y et al. 2018. Cell. 174(3):536-548 . PubMed
  223. Zhu Y, et al. 2017. Lab Chip. 10.1039/c7lc00682a. PubMed
  224. Metzger JJ, et al. 2022. Cell Rep Methods. 2:100297. PubMed
  225. Marinopoulou E, et al. 2021. iScience. 24:103198. PubMed
  226. Chai G, et al. 2020. Neuron. 109(2):241-256.e9. PubMed
  227. Yu Q, et al. 2021. eLife. 10:00. PubMed
  228. Miyashita H, et al. 2017. Sci Rep. 7:43557. PubMed
  229. Tang K, et al. 2012. Development. 139:1630-1639. PubMed
  230. He S, et al. 2016. Development. 143: 1937 - 1947. PubMed
  231. Lajko M, et al. 2016. PLoS One. 11:e0166886. PubMed
  232. Hasenpusch–Theil K, et al. 2020. eLife. 9:e58162. PubMed
  233. Bendriem RM, et al. 2020. eLife. 8:e49376.. PubMed
  234. Wu X, et al. 2018. Cell. 172:423. PubMed
  235. Shibata S et al. 2018. Cell reports. 25(6):1668-1679 . PubMed
  236. Thomas Klein et al. 2018. Stem cell research. 33:171-174 . PubMed
  237. Ward JM, et al. 2019. Cell Rep. 26:1189. PubMed
  238. Wang S, et al. 2019. Protein Cell. 10:1. PubMed
  239. Watanabe Y, et al. 2018. Development. 145. PubMed
  240. Wu Z, et al. 2019. Neuron. 101:635. PubMed
  241. Miesfeld JB, et al. 2018. Sci Rep. 8:10195. PubMed
  242. Liang D, et al. 2021. Nat Neurosci. 24:941. PubMed
  243. Vajhøj C, et al. 2021. PLoS One. 16:e0261536. PubMed
  244. Nieto-Estévez V, et al. 2022. Front Mol Neurosci. 14:815808. PubMed
  245. Nieto-Estévez V, et al. 2022. Front Mol Neurosci. 15:889922. PubMed
  246. Li M, et al. 2021. Signal Transduct Target Ther. 6:05. PubMed
  247. Kitajima R, et al. 2020. Stem Cell Res. 101749:44. PubMed
  248. Inak G, et al. 2021. Nat Commun. 12:1929. PubMed
  249. C Tao, X Zhang, 2016. Cell Rep. 17:1832-1844. PubMed
  250. Damiani D, et al. 2016. Nat Commun. 7:13509. PubMed
  251. Toda T, et al. 2016. Sci Rep. 6:29578. PubMed
  252. Anda F, et al. 2016. Nat Neurosci. 10.1038/nn.4328. PubMed
  253. Martínez-Cerdeño V, et al. 2016. Cereb Cortex. 26: 374 - 383. PubMed
  254. Yao H, et al. 2020. Sci Rep. 10:17445. PubMed
  255. Ding W, et al. 2019. J Neurosci. 39:1994. PubMed
  256. Gao ML, et al. 2020. Front Cell Dev Biol. 8:128. PubMed
  257. Gao F et al. 2019. Mol Cell. 75(5):891-904 . PubMed
  258. Sanchez–Guardado L, et al. 2019. Elife. 8:e46675. PubMed
  259. Kurabayashi N, et al. 2018. Development. 145. PubMed
  260. Kawaue T, et al. 2019. Nat Commun. 10:2780. PubMed
  261. Nowakowski TJ, et al. 2018. Nat Neurosci. 21:1784. PubMed
  262. Baizabal JM et al. 2018. Neuron. 98(5):945-962 . PubMed
  263. Lin L, et al. 2020. Neuron. 107:1180. PubMed
  264. Aldinger KA, et al. 2021. Nat Neurosci. 24:1163. PubMed
  265. Carpentieri JA, et al. 2022. Nat Commun. 13:16. PubMed
  266. Meng Y, et al. 2021. Front Cell Dev Biol. 9:702462. PubMed
  267. Mathieu C, et al. 2021. MBio. 12:e0079921. PubMed
  268. Conrad E, et al. 2016. Am J Physiol Endocrinol Metab. 310: E91 - E102. PubMed
  269. Wang L, Hou S, Han Y 2016. Nat Neurosci. 19: 888-896. PubMed
  270. Abdullah A, et al. 2016. Stem Cell Reports. 7:69-79. PubMed
  271. Yan P, et al. 2020. Cell Rep. 32:107870. PubMed
  272. Thomas Klein et al. 2018. Stem cell research. 31:222-226 . PubMed
  273. Han S, et al. 2018. Development. 145:. PubMed
  274. Palencia–Campos A, et al. 2017. Hum Mol Genet. 26:4556. PubMed
  275. Karzbrun E, et al. 2018. Nat Phys. 14:515. PubMed
  276. Mochizuki T, et al. 2017. Development. 144:708. PubMed
  277. Alzu'bi A et al. 2019. Journal of anatomy. 235(3):555-568 . PubMed
  278. Arber C, et al. 2021. Cell Reports. 34(2):108615. PubMed
  279. Kweon H, et al. 2021. Cell Reports. 34(8):108780. PubMed
  280. Bowles KR, et al. 2021. Cell. 184(17):4547-4563.e17. PubMed
  281. Campbell WA, et al. 2021. Glia. 69:1515. PubMed
  282. Li Z, et al. 2020. ACS Infect Dis. 6:2616. PubMed
  283. Too LK, et al. 2021. Retina. 41:1986. PubMed
  284. Wind M, et al. 2021. Curr Protoc. 1:e244. PubMed
  285. Cugola F, et al. 2016. Nature. 534: 267-271. PubMed
  286. Radonjić N, et al. 2016. Cereb Cortex. 26: 131 - 143. PubMed
  287. Todd L, et al. 2018. Stem Cells. 36:392. PubMed
  288. Segarra M, et al. 2018. Science. 361:eaao2861. PubMed
  289. Jin J, et al. 2019. PLoS One. 14:e0219362. PubMed
  290. Alexander JM et al. 2019. Elife. 8 pii: e41769. PubMed
  291. Zurkirchen L, et al. 2019. Nat Commun. 10:2192. PubMed
  292. Diacou R et al. 2018. Cell reports. 25(9):2510-2523 . PubMed
  293. Tang Y et al. 2018. Cell reports. 24(5):1355-1362 . PubMed
  294. Krach F, et al. 2022. Nat Commun. 13:6797. PubMed
  295. Arnst N, et al. 2021. Cells. 10:. PubMed
  296. Bockaj I, et al. 2021. PLoS Genet. 17:e1009868. PubMed
  297. Korecki AJ, et al. 2021. Gene Ther. 28:351. PubMed
  298. Besusso D, et al. 2020. Stem Cell Res. 102016:49. PubMed
  299. Jia N, et al. 2021. Stem Cell Research. 53:102367. PubMed
  300. Somatilaka BN, et al. 2020. Developmental Cell. 54(6):710-726.e8. PubMed
  301. Verheyen A, et al. 2015. PLoS One. 10: 0146127. PubMed
  302. Takeo Y, et al. 2016. Sci Rep. 6: 25180. PubMed
  303. Plaisted W, et al. 2016. PLoS One. 11: 0157620. PubMed
  304. Feng J, et al. 2016. Cereb Cortex. 26: 3323 - 3334. PubMed
  305. Zhang Y et al. 2018. Cell stem cell. 23(4):516-529 . PubMed
  306. Le Dréau G, et al. 2018. Elife. 7:e7267. PubMed
  307. Broix L, et al. 2018. Hum Mol Genet. 27:224. PubMed
  308. Dominguez Gonzalez B, et al. 2018. Hum Mol Genet. 27:2154. PubMed
  309. Ooi J, et al. 2019. Cell Rep. 26:2494. PubMed
  310. Hu XL, et al. 2017. Neuron. 95:309. PubMed
  311. Chang CH, et al. 2019. Dev Cell. 48:184. PubMed
  312. Ferdaos N, et al. 2022. PLoS One. 17:e0278147. PubMed
  313. Penna E, et al. 2021. Cereb Cortex Commun. 2:tgab053. PubMed
  314. Kaufman ML, et al. 2021. Development. 148:. PubMed
  315. Yao X, et al. 2022. Nat Commun. 13:3883. PubMed
  316. Yang Y, et al. 2022. Front Bioeng Biotechnol. 10:907159. PubMed
  317. Tsai MH, et al. 2020. Acta Neuropathol Commun. 0.406944444. PubMed
  318. Cederquist GY, et al. 2020. Cell Stem Cell. 27(1):35-49.e6. PubMed
  319. Haag D, et al. 2021. Cancer Cell. 39(3):407-422.e13. PubMed
  320. Bannier-Hlaout M, et al. 2021. Cell Stem Cell. 28(7):1221-1232.e7. PubMed
  321. Tolomeo AM, et al. 2021. Front Cell Neurosci. 602888:15. PubMed
  322. Chen Y, et al. 2021. Nat Methods. 18:528. PubMed
  323. Wiley L, et al. 2016. Sci Rep. 6:30742. PubMed
  324. Laan L, et al. 2020. Clin Epigenetics. 12:09. PubMed
  325. Liu Z, et al. 2019. Cell Rep. 27:3832. PubMed
  326. Roy A et al. 2019. Elife. 8 pii: e45961. PubMed
  327. Cargnin F, et al. 2018. Neuron. 100:1083. PubMed
  328. Barra JM, et al. 2021. Xenotransplantation. 28:e12706. PubMed
  329. Zhang YF, et al. 2022. Front Cell Neurosci. 16:866020. PubMed
  330. Zhang XZ, et al. 2022. Front Cell Neurosci. 16:888152. PubMed
  331. Torsahakul C, et al. 2022. PLoS One. 17:e0263141. PubMed
  332. Klein JA, et al. 2022. Front Cell Neurosci. 15:794675. PubMed
  333. Patel A, et al. 2020. Development. dev193649. PubMed
  334. Žagare A, et al. 2021. STAR Protoc. 2:100524. PubMed
  335. Gao X, et al. 2021. Stem Cell Research. 53:102388. PubMed
  336. Li Z, et al. 2020. Emerg Microbes Infect. 2.044444444. PubMed
  337. Hayashi R, et al. 2017. Nat Protoc. 10.1038/nprot.2017.007. PubMed
RRID
AB_2565003 (BioLegend Cat. No. 901302)
AB_2565003 (BioLegend Cat. No. 901301)

Antigen Details

Cell Type
Neural Stem Cells
Biology Area
Cell Biology, Neuroscience, Neuroscience Cell Markers, Signal Transduction, Stem Cells, Synaptic Biology, Transcription Factors
Molecular Family
Nuclear Markers
Gene ID
5080 View all products for this Gene ID 18508 View all products for this Gene ID 25509 View all products for this Gene ID
UniProt
View information about Pax-6 on UniProt.org

Other Formats

View All Pax-6 Reagents Request Custom Conjugation
Description Clone Applications
Purified anti-Pax-6 Poly19013 WB,IHC-P,IHC-F
Go To Top Version: 9    Revision Date: 08/24/2021

For Research Use Only. Not for diagnostic or therapeutic use.

 

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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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