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APC anti-human CD41 Antibody

Pricing & Availability
Clone
HIP8 (See other available formats)
Regulatory Status
RUO
Workshop
IV P38
Other Names
gpIIb, CD41a
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
HIP8
Human platelets stained with HIP8 PE
  • HIP8
    Human platelets stained with HIP8 PE
Compare all formats See APC spectral data
Cat # Size Price Save
303709 25 tests ¥30,580
303710 100 tests ¥54,870
Description

CD41 is a 125/25 kD α subunit of the gpIIb/IIIa (CD41/CD61) complex. CD41 is a heterodimer composed of a heavy chain (gpIIbα) and light chain (gpIIbβ) linked by a single disulfide bond. It is a member of the integrin family primarily expressed on platelets and megakaryocytes. CD41 has been reported to be involved with platelet aggregation and platelet attachment to the ECM. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, and thrombin.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Capuchin Monkey, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Red Laser (633 nm)
Application Notes

Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections and blocking of platelet aggregation2. The HIP8 antibody has been reported to block the activation of platelets by various stimuli, including collagen, and ADP.

Application References

(PubMed link indicates BioLegend citation)
  1. Knapp W, et al. 1989. Leucocyte Typing IV. Oxford University Press. New York.
  2. McCarty OJT, et al. 2000. Blood 96:1789.
  3. Yoshino N, et al. 2000. Exp. Anim. (Tokyo) 49:97. (FC)
  4. Zhi L et al. 2013. PLoS One. 8:e79869. (IHC)
Product Citations
  1. Shen WY, et al. 2023. iScience. 26:106805. PubMed
  2. Dickerson KM, et al. 2022. Blood Cancer Discov. 3:240. PubMed
  3. Liu Y, et al. 2022. Signal Transduct Target Ther. 7:347. PubMed
  4. Moussa M, et al. 2016. J Biomater Appl. 30: 1219 - 1229. PubMed
  5. Machata S, et al. 2021. Front Immunol. 11:565869. PubMed
  6. Botha J, et al. 2021. Biomedicines. 9:. PubMed
  7. Pircher J, et al. 2018. Nat Commun. 32:364. PubMed
  8. Wang B, et al. 2022. Cell Discov. 8:41. PubMed
  9. Best MG et al. 2017. Cancer cell. 32(2):238-252 . PubMed
  10. Hug S, et al. 2021. Front Immunol. 12:642867. PubMed
  11. Sung PS, et al. 2019. Nat Commun. 10:2402. PubMed
  12. Rodda LB, et al. 2020. Cell. 184(1):169-183.e17. PubMed
  13. Sato M, et al. 2021. Spine Surg Relat Res. 5:196. PubMed
  14. Zhang G, et al. 2021. Front Pharmacol. 12:705325. PubMed
  15. Shlamkovich T, et al. 2020. BMC Biology. 16(1):92. PubMed
  16. Pellin D, et al. 2019. Nat Commun. 10:2395. PubMed
  17. Ito Y, et al. 2018. Cell. 174:636. PubMed
  18. Palacios-Acedo AL, et al. 2021. Front Oncol. 11:704945. PubMed
  19. Guo Q, et al. 2022. Blood Adv. 6:5668. PubMed
  20. Suzuki D, et al. 2020. Stem Cell Reports. 14:49. PubMed
  21. Costa B, et al. 2019. Blood Adv. 3:1092. PubMed
RRID
AB_2129464 (BioLegend Cat. No. 303709)
AB_2129464 (BioLegend Cat. No. 303710)

Antigen Details

Structure
Integrin family, α subunit of CD41/CD61 (GPIIb-IIIa) complex, 125/22 kD
Distribution

Platelets, megakaryocytes

Function
Platelet aggregation, platelet attachment to extracellular matrix
Ligand/Receptor
Fibrinogen, fibronectin, von Willebrand factor, thrombin
Cell Type
Megakaryocytes, Platelets
Biology Area
Cell Adhesion, Cell Biology, Immunology
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Denzin L, et al. 1996. J. Exp. Med. 184:2153.
2. Denzin L, et al. 1995. Cell 82:155.
3. Riberdy J, et al. 1994. J. Cell Biol. 125:1225.

Gene ID
3674 View all products for this Gene ID
Specificity (DOES NOT SHOW ON TDS):
CD41
Specificity Alt (DOES NOT SHOW ON TDS):
CD41
App Abbreviation (DOES NOT SHOW ON TDS):
FC
UniProt
View information about CD41 on UniProt.org
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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