APC anti-human TSPAN33 (BAAM) Antibody, TSPAN33, SA17RN1

Clone: SA17RN1 (See other available formats)
Regulatory Status: RUO
Other Names: Tetraspanin-33, BAAM, Penumbra, PEN
Isotype: Mouse IgG2b, κ
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Product Citations: publications

Human peripheral blood lymphocytes were stimulated overnight with recombinant human CD40L (TNFSF5) plus IL-4 and were stained with CD19 FITC and TSPAN33 (BAAM) (clone SA17RN1) APC (left) or Mouse IgG2b, κ APC isotype control (right).

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Cat #	Size	Price	Save
395405	25 tests	¥39,160
395406	100 tests	¥78,100

Description

TSPAN33, also known as BAAM, is a 32 kDa protein member of the TM4 superfamily (TM4SF). TSPAN33 have four transmembrane regions and two extracellular loops, one of them is a cysteine-rich long extracellular loop (LEL), characteristic of the TM4SF. TSPAN33 interacts with different molecules such as integrins and other tetraspanins. TSPAN33 is expressed by activated B cells, some B cell lymphomas, macrophages and in cells from the convoluted tubules and collecting ducts in the kidney. In macrophages TSPAN33 modulates TLR-induced proinflammatory gene expression, but its function in other cells is unknown.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Human TSPAN33-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Excitation Laser: Red Laser (633 nm)
RRID: AB_2801043 (BioLegend Cat. No. 395405)
AB_2801043 (BioLegend Cat. No. 395406)

Antigen Details

Structure: Member of the TM4 superfamily, TspanC8 subgroup, 32kD, 4 transmembrane regions, 1 cysteine-rich long extracellular loop (LEL).
Distribution: Activated B cells, some B cell lymphomas, macrophages, convoluted tubules and collecting ducts from kidney
Function: Modulates TLR-induced proinflammatory gene expression
Cell Type: B cells, Macrophages
Biology Area: Cancer Biomarkers, Immuno-Oncology, Signal Transduction
Molecular Family: Adhesion Molecules
Antigen References: Pérez-Martínez CA, et al. 2017. Scand J Immunol. 86:23.

Ruiz-García A, et al. 2016. J Immunol. 197:3371.

Luu VP, et al. 2013. Clin Immunol. 149:388.

Chen Z, et al. 2005. Cancer Genet Cytogenet. 162:95.

Maecker HT et al. 1997. FASEB J. 11:428.
Gene ID: 340348 View all products for this Gene ID
UniProt: View information about TSPAN33 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Pathways

Toll-Like Receptors

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Other Formats

View All TSPAN33 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human TSPAN33 (BAAM)	SA17RN1	FC
PE anti-human TSPAN33 (BAAM)	SA17RN1	FC
APC anti-human TSPAN33 (BAAM)	SA17RN1	FC
Biotin anti-human TSPAN33 (BAAM)	SA17RN1	FC
Brilliant Violet 421™ anti-human TSPAN33 (BAAM)	SA17RN1	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 04/08/2019

For Research Use Only. Not for diagnostic or therapeutic use.

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

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