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- Clone
- 11C3.1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Gp34, OX40L, CD134L, CD252, TNFSF4
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human endothelial cells (HUVEC) stained with biotinylated 11C3.1, followed by Sav-PE
OX40 ligand (OX40L) is a 35 kD type II transmembrane protein which belongs to TNF superfamily, also known as gp34, CD252, CD134L or TNFSF4. The OX40 ligand is expressed on activated B cells, activated endothelial cells, mature dendritic cells, activated CTLs, activated mast cells, and airway smooth muscle cells. OX40 ligand interacts with OX40 antigen (CD134) expressed predominantly on activated T cells to regulate T cell proliferation and differentiation, and to enhance immunoglobulin secretion by activated B cells.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Reported Reactivity
- African Green
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2303694 (BioLegend Cat. No. 326306)
Antigen Details
- Structure
- NGF/TNF superfamily, 35 kD
- Distribution
-
Activated B cells, activated endothelial cells, mature dendritic cells, airway smooth muscle cells
- Function
- B-cell/T-cell interaction, costimulation
- Ligand/Receptor
- OX40 (CD134)
- Cell Type
- B cells, Dendritic cells, Endothelial cells
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
-
1. Imura A, et al. 1996. J. Exp. Med. 183:2185.
2. Ohshima Y, et al. 1997. J. Immunol. 159:3838.
3. Ito T, et al. 2005. J. Exp.Med. 202:1213.
4. Ito T, et al. 2006. Proc. Natl. Acad.Sci. USA. 103:13138. - Gene ID
- 7292 View all products for this Gene ID
- UniProt
- View information about CD252 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Other Formats
View All CD252 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD252 (OX40L) | 11C3.1 | FC |
| Biotin anti-human CD252 (OX40L) | 11C3.1 | FC |
| PE anti-human CD252 (OX40L) | 11C3.1 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD252 (OX40L)
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Biotin anti-human CD252 (OX40L)
Human endothelial cells (HUVEC) stained with biotinylated 11... -
PE anti-human CD252 (OX40L)
GM-CSF-stimulated human peripheral blood monocytes (day-3) s...
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