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- Clone
- TLR6.127 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- TLR6, CD286
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood monocytes stained with biotinylated TLR6.127, followed Sav-PE
Toll-like receptors (TLRs) are type I transmembrane signaling receptors characterized by containing leucine-rich repeats (LRR) extracellular domain and IL-1 receptor like intracellular domain. TLRs are responsible for recognizing pathogen-associated molecule patterns (PAMPs). They are primary sensors of both innate and adaptive immune systems. To date a total of 12 TLRs have been identified. Toll-like receptor 6 (TLR6), known as CD286, is one of the important receptors. TLR6 is colocalized with TLR2 on the cell surface of monocytes/macrophages, dendritic cells, granulocytes. The TLR2/TLR6 complex plays a role in the innate immune response to diacylated lipoprotein and peptidoglycan antigens.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human TLR6 transfected Ba/F3 cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Additional reported applications include: blocks cytokine production induced by MALP-2 and peptidoglycan(1)
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Application References
(PubMed link indicates BioLegend citation) -
- Nakao Y, et al. 2005. J. Immunol. 174:1566
- RRID
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AB_1186049 (BioLegend Cat. No. 334705)
Antigen Details
- Structure
- Type I transmembrane protein characterized by containing leucine-rich repeats (LRR) extracellular domain and IL-1 receptor like intracellular domain, colocalized with TLR2 at the cell surface
- Distribution
- Monocytes/macrophages, dendritic cells, granulocytes
- Function
- Activates innate host defense against diverse set of pathogens
- Ligand/Receptor
- Diacylated lipoprotein, peptidoglycan
- Cell Type
- Monocytes, Macrophages, Dendritic cells, Granulocytes
- Biology Area
- Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
- Molecular Family
- CD Molecules, Toll Like Receptors
- Antigen References
-
1. Takeuchi O, et al. 2001. Int. Immunol. 13:933
2. Shimizu T, et al. 2005. J. Immunol. 175:4641
3. Into T, et al. 2004. Cell Microbiol. 6:187 - Gene ID
- 10333 View all products for this Gene ID
- UniProt
- View information about CD286 on UniProt.org
Related Pages & Pathways
Pathways
Related FAQs
- How many biotin molecules are per antibody structure?
- We don't routinely measure the number of biotins with our antibody products but the number of biotin molecules range from 3-6 molecules per antibody.
Other Formats
View All CD286 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD286 (TLR6) | TLR6.127 | FC |
| Biotin anti-human CD286 (TLR6) | TLR6.127 | FC |
| PE anti-human CD286 (TLR6) | TLR6.127 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD286 (TLR6)
Human peripheral blood monocytes stained with purified TLR6.... -
Biotin anti-human CD286 (TLR6)
Human peripheral blood monocytes stained with biotinylated T... -
PE anti-human CD286 (TLR6)
Human peripheral blood monocytes stained with TLR6.127 PE
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