- Clone
- TS1/8 (See other available formats)
- Workshop
- V S025
- Other Names
- LFA-2, T11, SRBC-R
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
CD2 is a 50 kD type I transmembrane glycoprotein also known as LFA-2, T11, and sheep red blood cell receptor (SRBC-R). This immunoglobulin superfamily member is expressed on thymocytes, T lymphocytes, NK cells, and thymic B cell subsets. The major ligand for CD2 is CD58 (also known as LFA-3). CD2 has also been reported to bind CD48, CD59, and CD15. CD2 plays a critical role in alternative T cell activation, T cell signaling, and cell-cell adhesion.
Product DetailsProduct Details
- Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing True-Stain Monocyte Blocker™, 0.09% sodium azide and 0.2% (w/v) BSA (origin USA) and a stabilizer.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with APC/Fire™ 750 under optimal conditions.
- Concentration
- 50.0 µg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
* APC/Fire™ 750 has a maximum excitation of 650 nm and a maximum emission of 774 nm.
- Excitation Laser
-
Red Laser (633 nm)
- Application Notes
-
Additional reported applications (for the relevant formats) include: blocking of T cell activation, and partial blocking of B cell costimulation2. The Ultra-LEAF™ purified antibody (Endotoxin < 0.01 EU/µg, Azide-Free, 0.2 µm filtered) is recommended for functional assays (Cat. Nos. 309235 & 309236).
-
Application References
(PubMed link indicates BioLegend citation) -
- Schlossman S, et al. Eds.1995. Leucocyte Typing V Oxford University Press. New York.
- Hughes CCW, et al. 1996. J. Biol. Chem. 271:5369.
- Disclaimer
-
GMP RUO Flow Cytometry Antibodies. BioLegend GMP RUO fluorophore conjugated antibodies are manufactured in a dedicated GMP facility and compliant with ISO 13485:2016. For research use only. Not for use in diagnostic or therapeutic procedures. Our processes include:
- Batch-to-batch consistency
- Material traceability
- Documented procedures
- Documented employee training
- Equipment maintenance and monitoring records
- Lot-specific certificates of analysis
- Quality audits per ISO 13485:2016
- QA review of released products
Antigen Details
- Structure
- Ig superfamily, type I transmembrane glycoprotein, 50 kD
- Distribution
-
T cells, NK cells, thymocytes, and thymic B cell subsets
- Function
- T cell activation, adhesion
- Ligand/Receptor
- CD58 (LFA-3), CD48, CD59, CD15
- Cell Type
- B cells, NK cells, T cells, Thymocytes
- Biology Area
- Costimulatory Molecules, Immunology
- Molecular Family
- CD Molecules
- Antigen References
-
1. Bell G, et al. 1995. J. Immunol. 155:2805.
2. Bierer B, et al. 1989. Annu. Rev. Immunol. 7:579.
3. Moingeon P, et al. 1989. Immunol. Rev. 111:111. - Gene ID
- 914 View all products for this Gene ID
- UniProt
- View information about CD2 on UniProt.org
Related FAQs
Other Formats
View All CD2 Reagents Request Custom ConjugationCompare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
FITC anti-human CD2
Human peripheral blood lymphocytes stained with TS1/8 FITC -
PE anti-human CD2
Whole blood lymphocytes stained with TS1/8 PE -
Purified anti-human CD2
Human peripheral blood lymphocytes stained with purified TS1... -
Pacific Blue™ anti-human CD2
Human peripheral blood lymphocytes stained with TS1/8 Pacifi... -
PE/Cyanine7 anti-human CD2
Human peripheral blood lymphocytes stained with TS1/8 PE/Cya... -
Brilliant Violet 421™ anti-human CD2
Human peripheral blood lymphocytes stained with (clone TS1/8... -
Purified anti-human CD2 (Maxpar® Ready)
Human PBMCs stained with 151Eu anti-CD2 (TS1/8) and 170Er an... -
PerCP/Cyanine5.5 anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
APC anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
APC/Fire™ 750 anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
Alexa Fluor® 700 anti-human CD2
Human peripheral blood lymphocytes stained with CD3 Brillian... -
TotalSeq™-A0367 anti-human CD2
-
TotalSeq™-C0367 anti-human CD2
-
FITC anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
TotalSeq™-B0367 anti-human CD2
-
Ultra-LEAF™ Purified anti-human CD2
Human peripheral blood lymphocytes stained with Ultra-LEAF™ ... -
APC/Cyanine7 anti-human CD2
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
TotalSeq™-D0367 anti-human CD2
-
PE/Cyanine7 anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
PerCP/Cyanine5.5 anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
GMP PE anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
APC anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
APC/Fire™ 750 anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
Pacific Blue™ anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
GMP FITC anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
GMP APC/Fire™ 750 anti-human CD2
Typical results from human peripheral blood lymphocytes stai... -
PE/Dazzle™ 594 anti-human CD2
Human peripheral blood lymphocytes were stained with anti-hu...
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