- Clone
- S19005E (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Killer Cell Lectin Like Receptor C2, KLRC2, NK Cell Receptor C
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
---|---|---|---|
375003 | 25 tests | ¥36,300 | |
375004 | 100 tests | ¥89,760 |
CD159c, also known as NKG2C or KLRC2, is a type II transmembrane protein. It belongs to the killer cell lectin-like receptor family also known as the NKG2 family. It is expressed on NK and NKT cells and T cell subsets. NKG2C is an activating NK cell receptor and it is expressed as a heterodimer with CD94. In humans, the NKG2C/CD94 complex interacts with HLA-E on target cells and delivers activating signals through immunoreceptor tyrosine-based activation motifs.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human NKG2C/CD94-transfectants
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
S19005E does not crossreact with mouse CD159c.
- Product Citations
-
- RRID
-
AB_2888871 (BioLegend Cat. No. 375003)
AB_2888871 (BioLegend Cat. No. 375004)
Antigen Details
- Structure
- Type II transmembrane proteins of the C-type lectin superfamily
- Distribution
-
NK cells, NKT cells, T cell subsets
- Function
- Activating NK cell receptor
- Ligand/Receptor
- HLA-E
- Cell Type
- Lymphocytes, NK cells, NKT cells, T cells
- Biology Area
- Immuno-Oncology, Immunology
- Molecular Family
- Immune Checkpoint Receptors
- Antigen References
-
- Malisheni M, et al. 2017. Front Immunol. 8:863.
- Sáez-Borderías A, et al. 2009. J Immunol, 182:829.
- Kamiya T, et al. 2019. J. Clin. Invest. 129:2094.
- Gene ID
- 3822 View all products for this Gene ID
- UniProt
- View information about CD159c on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD159c (NKG2C) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD159c (NKG2C) | S19005E | FC |
PE anti-human CD159c (NKG2C) | S19005E | FC |
TotalSeq™-C1375 anti-human CD159c (NKG2C) | S19005E | PG |
TotalSeq™-D1375 anti-human CD159c (NKG2C) | S19005E | PG |
TotalSeq™-B1375 anti-human CD159c (NKG2C) | S19005E | PG |
TotalSeq™-A1375 anti-human CD159c (NKG2C) | S19005E | PG |
Brilliant Violet 421™ anti-human CD159c (NKG2C) | S19005E | FC |
Brilliant Violet 785™ anti-human CD159c (NKG2C) | S19005E | FC |
PE anti-human CD159c | S19005E | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human CD159c (NKG2C)
Human peripheral blood lymphocytes were stained with purifie... -
PE anti-human CD159c (NKG2C)
Human peripheral blood lymphocytes were stained with CD3 FIT... -
TotalSeq™-C1375 anti-human CD159c (NKG2C)
-
TotalSeq™-D1375 anti-human CD159c (NKG2C)
-
TotalSeq™-B1375 anti-human CD159c (NKG2C)
-
TotalSeq™-A1375 anti-human CD159c (NKG2C)
-
Brilliant Violet 421™ anti-human CD159c (NKG2C)
Human peripheral blood lymphocytes were stained with anti-hu... -
Brilliant Violet 785™ anti-human CD159c (NKG2C)
Human peripheral blood lymphocytes were stained with anti-hu... -
PE anti-human CD159c
Typical results from human peripheral blood lymphocytes stai...
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