- Clone
- QA20A43 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Lutheran antigen. Basal Cell Adhesion Molecule (B-CAM, Lutheran blood group). B-CAM cell surface glycoprotein
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
---|---|---|---|
378803 | 25 tests | ¥40,040 | |
378804 | 100 tests | ¥83,600 |
QA20A43 recognizes human CD239, also known as Lutheran antigen or Basal Cell Adhesion Molecule (B-CAM). Human CD239 is a type I transmembrane glycoprotein that is encoded by B-CAM which belongs to the Ig gene superfamily. Full-length BCAM (CD239) is comprised of an extracellular region with two N-terminal V-type Ig-like domains followed by three C2-type Ig-like domains, a transmembrane region, and cytoplasmic domain of 59 amino acid residues. CD239 is expressed on erythrocytes in the peripheral blood and on the basal layer of vascular endothelial cells or some epithelial cells.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µL per million cells in 100 µL staining volume or 5 µL per 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
- Application Notes
-
Clone QA20A43 can completely block the binding of positive clone to target cells.
- RRID
-
AB_2936741 (BioLegend Cat. No. 378803)
AB_2936741 (BioLegend Cat. No. 378804)
Antigen Details
- Structure
- ~85 kD single pass type I membrane glycoprotein
- Distribution
-
Erythrocytes in the peripheral blood and on the basal layer of vascular endothelial cells or some epithelial cells
- Function
- CD239 is upregulated upon malignant transformation of some cell types including those found in ovarian carcinomas and plays a role in epithelial cell cancer and in the vaso-occlusion of red blood cells in sickle cell disease.
- Ligand/Receptor
- CD239 is a receptor for the extracellular matrix protein, laminin
- Cell Type
- Antigen-presenting cells, Endothelial cells, Epithelial cells, Erythrocytes
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules, Soluble Receptors
- Antigen References
-
- El Nemer W, et al. 1998. J Biol Chem. 273:16686-93.
- Parsons SF, et al. 1997. Blood. 89:4219-25.
- Gene ID
- 4059 View all products for this Gene ID
- UniProt
- View information about CD239/B-CAM on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All CD239/B-CAM Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD239/B-CAM Recombinant Antibody | QA20A43 | FC |
PE anti-human CD239/B-CAM Recombinant Antibody | QA20A43 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD239/B-CAM Recombinant Antibody
Human peripheral red blood cells were stained with purified ... -
PE anti-human CD239/B-CAM Recombinant Antibody
Human peripheral red blood cells were stained with anti-huma...
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