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PE anti-human CD87 Antibody

Pricing & Availability
Clone
VIM5 (See other available formats)
Regulatory Status
RUO
Workshop
VI MR13
Other Names
Urokinase plasminogen activator-receptor, uPA-R, uPAR
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
VIM5_PE_110308.jpg
Human peripheral blood granulocytes stained with VIM5 PE
  • VIM5_PE_110308.jpg
    Human peripheral blood granulocytes stained with VIM5 PE
See PE spectral data
Cat # Size Price Save
336905 25 tests ¥26,840
336906 100 tests ¥61,820
Description

CD87, known as urokinase plasminogen activator-receptor (uPAR), is a 36-68 kD single-chain glycophosphotidylinositol (GPI)-anchored glycoprotein. The extracellular region of CD87 consists of three homologous domains, D1, D2, and D3. Membrane-bound and soluble (D2D3) forms of uPAR have been reported. The membrane-bound CD87 is expressed on granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells and keratinocytes. CD87 plays a role in cell adhesion and chemotaxis through binding to β1, β2 and β3 integrins. CD87-bound uPA converts plasminogen to plasmin.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Reported Reactivity
African Green, Baboon, Cynomolgus, Rhesus
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
THP-1 (human myeloid cell line)
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application Notes

Additional reported applications include: VIM5 mAb binds to uPA binding-domain

Application References

(PubMed link indicates BioLegend citation)
  1. Schlossmant SF, et al. eds. 1995 Leukocyte Type V. Oxford University Press Inc, New York
  2. Gadd SJ, et al. 1990. Clin. Exp. Immunol 80:252
  3. Sillaber C, et al. 1997. J. Biol. Chem. 272:7824
RRID
AB_2165468 (BioLegend Cat. No. 336905)
AB_2165468 (BioLegend Cat. No. 336906)

Antigen Details

Structure
Glycophosphotidylinositol (GPI)-anchored glycoprotein, 36-68 kD
Distribution

Granulocytes, monocytes/macrophages, dendritic cells, fibroblasts, endothelial cells, keratinocytes.

Function
Convert plasminogen to plasmin, cell adhesion, chemotaxis
Ligand/Receptor
Urokinase plasminogen activator (uPA), vitronectin, β1, β2 and β3 integrins, kininogen
Cell Type
Dendritic cells, Endothelial cells, Fibroblasts, Granulocytes, Macrophages, Monocytes
Biology Area
Immunology
Molecular Family
CD Molecules
Antigen References

1. Beaufort N, et al. 2004. J. Immunol. 172:540
2. Tarui T, et al. 2001. J. Bio. Chem. 276:3983
3. Zola H, et al. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. A John Wiley & Sons Inc, Publication

Gene ID
5329 View all products for this Gene ID
UniProt
View information about CD87 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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Toll-Free Phone: 1-877-Bio-Legend (246-5343) Phone: (858) 768-5800 Fax: (877) 455-9587

This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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