- Clone
- 94b/FOLR2 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FR-BETA
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
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391703 | 25 tests | ¥31,020 | |
391704 | 100 tests | ¥79,200 |
Folate receptors beta (FR-β) is a member of a family of folate binding receptors that have diverse structural identities but mediate transport of folates into cells. FR-β is a GPI-anchored protein with high affinity for folic acid. It is postulated that this receptor function as folate scavengers when folate supply is low or rapid cell growth requires elevated uptake of folate for methylation reactions including DNA biosynthesis. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human Folate beta transfected cells
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Nagayoshi R, et al. 2005. Arthritis Rheum. 9:2666
- Product Citations
-
- RRID
-
AB_2721335 (BioLegend Cat. No. 391703)
AB_2721335 (BioLegend Cat. No. 391704)
Antigen Details
- Structure
- 30 kD, seven disulfide bonds
- Distribution
-
Placenta, monocytes, tissue resident macrophages
- Function
- Transport of folate into cells
- Ligand/Receptor
- Folic Acid
- Cell Type
- Macrophages, Monocytes
- Biology Area
- Immunology
- Antigen References
-
- Elwood PC. 1989. J Biol Chem. 264:14893
- Shen F, et al. 1994. Biochemistry. 33:1209
- Yi YS. 2016. Immune Netw. 16:337
- Gene ID
- 2350 View all products for this Gene ID
- UniProt
- View information about Folate Receptor beta on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All Folate Receptor β (FR-β) Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | FC |
PE anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | FC |
APC anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | FC |
TotalSeq™-A0427 anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | PG |
TotalSeq™-B0427 anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | PG |
TotalSeq™-C0427 anti-human Folate Receptor β (FR-β) | 94b/FOLR2 | PG |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human Folate Receptor β (FR-β)
Human peripheral blood leukocytes were stained with FR-β (94... -
PE anti-human Folate Receptor β (FR-β)
Human peripheral blood monocytes were stained with CD14 FITC... -
APC anti-human Folate Receptor β (FR-β)
Human peripheral blood monocytes were stained with CD14 FITC... -
TotalSeq™-A0427 anti-human Folate Receptor β (FR-β)
-
TotalSeq™-B0427 anti-human Folate Receptor β (FR-β)
-
TotalSeq™-C0427 anti-human Folate Receptor β (FR-β)
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