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PE anti-mouse CD270 (HVEM) Antibody

Pricing & Availability
Clone
HMHV-1B18 (See other available formats)
Regulatory Status
RUO
Other Names
Herpes virus entry mediator, TR2, tumor necrosis factor receptor like 2, TNFRSF14, HVEM
Isotype
Armenian Hamster IgG
Ave. Rating
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Product Citations
publications
HMHV-1B18_PE_122209
C57BL/6 splenocytes stained with HMHV-1B18 PE
  • HMHV-1B18_PE_122209
    C57BL/6 splenocytes stained with HMHV-1B18 PE
Compare all formats See PE spectral data
Cat # Size Price Save
136303 25 µg ¥26,840
136304 100 µg ¥66,880
Description

Herpes Virus Entry Mediator (HVEM, TR2) is a type I transmembrane protein of TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HAS) entry. Binding of HSV viral envelope glycoprotein D to this receptor has been shown to be part of the viral entry mechanism. It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs. The ligands of HVEM are LIGHT, BTLA, LTα, and CD160. HVEM activates NF-kB through the TNF-related cytokine LIGHT to serve as a costimulatory pathway during T cell activation. HVEM also functions as a ligand for the Ig superfamily members B and T lymphocyte attenuator (BTLA) and CD160 to deliver a coinhibitory signal and limit inflammatory responses initiated by T cells. HVEM plays an important role in regulating lymphocyte activation and homeostasis in immune responses.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Mouse
Antibody Type
Monoclonal
Host Species
Armenian Hamster
Immunogen
Mouse HVEM-hIgG1Fc fusion protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation
The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions.
Concentration
0.2 mg/ml
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Product Citations
  1. Wakeley ME, et al. 2023. Front Med (Lausanne). 10:1176602. PubMed
  2. Verma S, et al. 2016. J Virol. 90: 650 - 658. PubMed
  3. Boice M et al. 2016. Cell. 167(2):405-418 . PubMed
  4. Knox T, et al. 2019. Sci Rep. 9:6136. PubMed
  5. Seo GY et al. 2018. Cell host & microbe. 24(2):249-260 . PubMed
RRID
AB_2203830 (BioLegend Cat. No. 136303)
AB_2203830 (BioLegend Cat. No. 136304)

Antigen Details

Structure
A type I transmembrane protein of TNF-receptor superfamily.
Distribution

It is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It is also found in brain, heart, kidney, liver, and other organs.

Function
Play an important role in regulating lymphocyte activation and homeostasis in immune responses.
Ligand/Receptor
LIGHT, BTLA, LTα, CD160
Cell Type
B cells, Dendritic cells, Neutrophils
Biology Area
Cell Adhesion, Cell Biology, Immunology, Signal Transduction
Molecular Family
Adhesion Molecules, CD Molecules
Antigen References

1. Fan Z, et al. 2006. Blood 107(4):1342
2. Granger SW, et al. 2008. Stem Cells. 27:653
3. Kwon BS, et al. 1997. J. Biol. Chem. 272:13471
4. Gonzalez LC, et al. 2005. Proc. Nat. Acad. Sci. U. S. A. 102:1116
5. Montgomery RI, et al. 1996. Cell. 87:427
6. Cheung TC, et al. 2009. Proc. Nat. Acad. Sci. U. S. A. 106 (15):6244
7. Cai G, et al. 2009. Immunol. Rev. 229(1):244

Gene ID
230979 View all products for this Gene ID
UniProt
View information about CD270 on UniProt.org

Related FAQs

What type of PE do you use in your conjugates?
We use R-PE in our conjugates.
Go To Top Version: 1    Revision Date: 11/30/2012

For Research Use Only. Not for diagnostic or therapeutic use.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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