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- Clone
- MR11-1 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Vβ12 T-cell receptor, T cell receptor beta 12
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
C57BL/6 mouse lymph node stained with TCR Vβ12 (MR11-1) PE and CD3 (145-2C11) APC
| Cat # | Size | Price | Save |
|---|---|---|---|
| 139703 | 25 µg | ¥22,970 | |
| 139704 | 100 µg | ¥47,710 |
T cell receptor Vβ12 (TCR Vβ12) is a variant of TCR β chain and, along with TCR α chain, forms the TCR heterodimer. In association with the CD3 complex, TCR α/β is responsible for antigen recognition through interaction with MHC-peptide complex to initiate the T cell-mediated immune responses. The MR11-1 antibody reacts with the Vβ12 TCR of mice bearing the b haplotype. It has been reported that Mtv-8 and Mtv-9 cause clonally deletion of Vβ12+ T cells.
Product DetailsProduct Details
- Verified Reactivity
- Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions.
- Concentration
- 0.2 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.06 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Excitation Laser
-
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
-
Application References
(PubMed link indicates BioLegend citation) -
- Joshi P, et al. 2006. J Leukoc Biol. 80:1345. (FC)
- Product Citations
-
- RRID
-
AB_10639729 (BioLegend Cat. No. 139703)
AB_10639729 (BioLegend Cat. No. 139704)
Antigen Details
- Structure
- Member of the immunoglobulin superfamily, Vβ12 is a variant of the TCR β chain which associates with the TCR α chain to form the TCR heterodimer
- Distribution
-
subset of TCR αβ+ T cells
- Function
- Recognition of peptides presented in the MHC molecules, responsible for T cell mediated immune responses
- Cell Type
- T cells
- Biology Area
- Adaptive Immunity, Immunology
- Molecular Family
- TCRs
- Gene ID
- 21577 View all products for this Gene ID
- UniProt
- View information about TCR Vbeta12 on UniProt.org
Related FAQs
- What type of PE do you use in your conjugates?
- We use R-PE in our conjugates.
Other Formats
View All TCR Vβ12 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-mouse TCR Vβ12 | MR11-1 | FC |
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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PE anti-mouse TCR Vβ12
C57BL/6 mouse lymph node stained with TCR Vβ12 (MR11-1) PE a...
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