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PE/Cyanine7 anti-human CD307c/FcRL3 Antibody

Pricing & Availability
Clone
H5/FcRL3 (See other available formats)
Regulatory Status
RUO
Other Names
Fc receptor-like 3 (FCRL3), Immune receptor translocation-associated protein 3 (IRTA3), SH2 domain-containing phosphatase anchor protein 2 (SPAP2), IFGP family protein 3 (IFGP3)
Isotype
Mouse IgG2b, κ
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Product Citations
publications
H5-FcRL3_PECyanine7_CD307c_Antibody_1_111623
Human peripheral blood lymphocytes were surface stained with CD3 APC and CD307c/FcRL3 PE/Cyanine7 (left) or mouse IgG2b, κ PE/Cyanine7 isotype control (right).
  • H5-FcRL3_PECyanine7_CD307c_Antibody_1_111623
    Human peripheral blood lymphocytes were surface stained with CD3 APC and CD307c/FcRL3 PE/Cyanine7 (left) or mouse IgG2b, κ PE/Cyanine7 isotype control (right).
Compare all formats See PE/Cyanine7 spectral data
Cat # Size Price Save
374409 25 tests ¥40,260
374410 100 tests ¥84,040
Description

CD307c is a type 1 transmembrane glycoprotein in the FcRL family of the Ig gene superfamily that is conserved in humans and not found in mice. It is expressed on NK cells, T cell, regulatory T cell, B cell and plasma cell subsets. Intracellular ITAM and ITIM motifs in conjunction with extracellular Ig domains are thought to play a role in the regulation of immune response, and autoimmune function. Impairment of normal FcRL3 function has been linked to systemic lupus erythematosus, rheumatoid arthritis, and autoimmune thyroid disease.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
FcRL3 full length expression plasmid DNA, followed by cell boost using transiently transfected cells with the same plasmid.
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and BSA (origin USA)
Preparation
The antibody was purified by affinity chromatography and conjugated with PE/Cyanine7 under optimal conditions.
Concentration
Lot-specific (to obtain lot-specific concentration and expiration, please enter the lot number in our Certificate of Analysis online tool.)
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is 5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.

Excitation Laser
Blue Laser (488 nm)
Green Laser (532 nm)/Yellow-Green Laser (561 nm)
Application References

(PubMed link indicates BioLegend citation)
  1. Nagata S, et al. 2009. J. Immunol. 182:7518-26.
RRID
AB_2728395 (BioLegend Cat. No. 374409)
AB_2728395 (BioLegend Cat. No. 374410)

Antigen Details

Distribution

NK, T, regulatory T, B, and plasma cell subsets.

Interaction
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6).
Cell Type
B cells, NK cells, Plasma cells, T cells, Tregs
Biology Area
Immunology
Molecular Family
CD Molecules, Fc Receptors
Antigen References

1. Bin Dhuban K, et al. 2015. J. Immunol. 194(8):3687-96.
2. Yuan M, et al. 2016. Mol. Neurobiol. 53:2029-35.
3. Fang Y, et al. 2016. Immunobiology. 221(1):56-62.

Gene ID
115352 View all products for this Gene ID
UniProt
View information about CD307c/FcRL3 on UniProt.org

Related FAQs

There are no FAQs for this product.
Go To Top Version: 1    Revision Date: 04/19/2018

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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