- Clone
- N103/39 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- FDH
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
---|---|---|---|
856801 | 25 µg | ¥18,260 | |
856802 | 100 µg | ¥36,300 |
Aldehyde dehydrogenase family 1 member L1 (ALDH1L1) was originally discovered as an enzyme that catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate, with NADPH and CO2 as by products. ALDH1L1 is most exclusively expressed by astroglial cells1 implicating these cells as the major components of folate-dependent formate oxidation in the brain.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
IHC-P - Verified
ICC, IHC-F - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 0.2 - 5.0 µg per mL. For immunohistochemistry on formalin-fixed paraffin-embedded tissue sections, a concentration range of 1.0 - 10 µg/mL is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Additional reported applications (for the relevant) formats include immunocytochemistry3 and immunohistochemistry on frozen tissue sections1.
-
Application References
(PubMed link indicates BioLegend citation) -
- Zuo H, et al. 2018. J Neurosci. 38(9):2359 (IHC-F)
- Kidana K, et al. 2018. EMBO Mol Med. 10:e8184 (WB)
- Tian E, et al. 2016. Cell Reports. 16:781 (ICC)
- RRID
-
AB_2783463 (BioLegend Cat. No. 856801)
AB_2783463 (BioLegend Cat. No. 856802)
Antigen Details
- Structure
- ALDH1L1 is a 902 amino acid protein with an apparent molecular mass of ~ 99 kD.
- Distribution
-
Tissue Distribution: Brain, Liver, Colon, and Kidney.
Cellular Distribution: Extracellular, cytosol, and plamsa membrane. - Function
- ALDH1L1 catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate.
- Biology Area
- Cell Biology, Neuroinflammation, Neuroscience, Neuroscience Cell Markers
- Antigen References
-
- Neymerer V, et al. 1997. Brain Res. 766(1-2): 195
- Brandebura AN, et al. 2018. Dev Neurobiol. doi: 10.1002/dneu.22633.
- Garwood CJ, et al. 2017. Neuropathol Appl Neurobiol. 43(4):281
- Gene ID
- 10840 View all products for this Gene ID 107747 View all products for this Gene ID
- UniProt
- View information about ALDH1L1 on UniProt.org
Related Pages & Pathways
Pages
Related FAQs
Other Formats
View All ALDH1L1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-ALDH1L1 | N103/39 | WB,IHC-P,ICC,IHC-F |
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