- Clone
- BSB-19 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CDM, CALD1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Caldesmon is a calmodulin-, actin-, and tropomyosin-binding protein that plays an essential role in smooth muscle and non-muscle contraction. This protein is also involved in cellular mitosis and Schwann cell migration during peripheral nerve regeneration.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic peptide corresponding to the N-terminus of the human Caldesmon protein.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
IHC-F, WB - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2629661 (BioLegend Cat. No. 846702)
Antigen Details
- Structure
- Caldesmon is a 793 amino acid protein with a molecular mass of 93 kD.
- Distribution
-
Tissue distribution: high-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Caldesmon is not expressed in skeletal muscle or heart..
Cellular distribution: cytoskeleton, cytosol, and plasma membrane. - Function
- Caldemon mainly regulates actomyosin interactions in smooth muscle and non-muscle cells which affects cell contractions. The protein is also involved in cellular mitosis and in Schwann cell migration during peripheral nerve regeneration.
- Interaction
- Calmodulin, actin, and tropomyosin.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure
- Molecular Family
- Enzymes and Regulators
- Antigen References
-
1. Huber PA. 1997. Int. J. Biochem. Cell Biol. 29(8-9):1047. PubMed
2. Mayanagi T, Sobue K. 2011. Cell. Adh. Migr. 5(2):150. PubMed
3. Wang CL. 2008. Adv. Exp. Med. Biol. 644:250. PubMed
4. Sobue K, Sellers JR. 1991. J. Biol. Chem. 266(19):12115. PubMed - Gene ID
- 800 View all products for this Gene ID
- UniProt
- View information about Caldesmon on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Caldesmon Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Caldesmon | BSB-19 | IHC-P,IHC-F,WB |
Compare Data Across All Formats
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Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-Caldesmon
IHC staining of anti-Caldesmon antibody (clone BSB-19) on fo...
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