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- Clone
- BSB-19 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CDM, CALD1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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IHC staining of anti-Caldesmon antibody (clone BSB-19) on formalin-fixed paraffin-embedded human uterus tissue. Following antigen retrieval using sodium citrate, the tissue was incubated with the primary antibody for one hour at room temperature at 1 µg/ml. BioLegend's Ultra-Streptavidin (USA) HRP Detection Kit was used for detection.
Caldesmon is a calmodulin-, actin-, and tropomyosin-binding protein that plays an essential role in smooth muscle and non-muscle contraction. This protein is also involved in cellular mitosis and Schwann cell migration during peripheral nerve regeneration.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Synthetic peptide corresponding to the N-terminus of the human Caldesmon protein.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
IHC-P - Quality tested
IHC-F, WB - Reported in the literature, not verified in house - Recommended Usage
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Each lot of this antibody is quality control tested by formalin-fixed paraffin-embedded immunohistochemical staining. For immunohistochemistry, a concentration range of 1.0 - 10 μg/ml is suggested. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2629661 (BioLegend Cat. No. 846702)
Antigen Details
- Structure
- Caldesmon is a 793 amino acid protein with a molecular mass of 93 kD.
- Distribution
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Tissue distribution: high-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Caldesmon is not expressed in skeletal muscle or heart..
Cellular distribution: cytoskeleton, cytosol, and plasma membrane. - Function
- Caldemon mainly regulates actomyosin interactions in smooth muscle and non-muscle cells which affects cell contractions. The protein is also involved in cellular mitosis and in Schwann cell migration during peripheral nerve regeneration.
- Interaction
- Calmodulin, actin, and tropomyosin.
- Biology Area
- Cell Biology, Cell Motility/Cytoskeleton/Structure
- Molecular Family
- Enzymes and Regulators
- Antigen References
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1. Huber PA. 1997. Int. J. Biochem. Cell Biol. 29(8-9):1047. PubMed
2. Mayanagi T, Sobue K. 2011. Cell. Adh. Migr. 5(2):150. PubMed
3. Wang CL. 2008. Adv. Exp. Med. Biol. 644:250. PubMed
4. Sobue K, Sellers JR. 1991. J. Biol. Chem. 266(19):12115. PubMed - Gene ID
- 800 View all products for this Gene ID
- UniProt
- View information about Caldesmon on UniProt.org
Related FAQs
Other Formats
View All Caldesmon Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-Caldesmon | BSB-19 | IHC-P,IHC-F,WB |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-Caldesmon
IHC staining of anti-Caldesmon antibody (clone BSB-19) on fo...
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