- Clone
- 3D5-C6-D5 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- DCTN1, Dynactin Subunit 1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
---|---|---|---|
867601 | 25 µg | ¥23,320 | |
867602 | 100 µg | ¥60,720 |
Dynactin 1 is the largest subunit of the macromolecular complex dynactin, which is essential for dynein-mediated retrograde transport of vesicles and organelles. Dynactin 1 is clinically identified as a causative gene for Perry syndrome (PS), which is a neurodegenerative disease characterized by autosomal dominant inheritance, parkinsonism, and central hypoventilation. Mutations in dynactin 1 are also associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Purified recombinant Dynactin 1 protein fragments expressed in E.coli.
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2814614 (BioLegend Cat. No. 867601)
AB_2814614 (BioLegend Cat. No. 867602)
Antigen Details
- Structure
- Dynactin 1 is a 1278 amino acid protein with two reported isoforms. A brain-specific isoform with predicted and observed molecular mass of ~135 kD, and a ubiquitously expressed isoform with predicted and observed molecular mass of ~150 kD.
- Distribution
-
Tissue Distribution: Ubiquitously expressed
Cellular Distribution: Cytoskeleton, cytosol, and nucleus - Function
- Dynactin 1 recruits dynein to microtubules and facilitates retrograde transport of vesicles and organelles.
- Interaction
- Dynactin 1 forms homodimer and interacts with dynein.
- Biology Area
- Cell Motility/Cytoskeleton/Structure, Neurodegeneration, Neuroscience, Protein Trafficking and Clearance, Synaptic Biology
- Molecular Family
- Adaptor Proteins, Carrier Proteins, Cytoskeletal Proteins, Neurotransmitter Receptor Trafficking/Endocytosis, Presynaptic proteins, Synaptic Vesicle Trafficking/Endocytosis
- Antigen References
-
- Konno T, et al. 2017. Parkinsonism Relat Disord. 41:14.
- Houlden H, et al. 2012. Acta Neuropath. 124(3):325.
- Tanaka F, et al. 2011. Rinsho Shinkeigaku. 51(11):1189.
- Gene ID
- 1639 View all products for this Gene ID
- UniProt
- View information about Dynactin 1 on UniProt.org
Other Formats
View All Dynactin 1 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Dynactin 1 (N-Terminus) | 3D5-C6-D5 | WB |
Compare Data Across All Formats
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Purified anti-Dynactin 1 (N-Terminus)
Western blot of purified anti-Dynactin 1 (N-Terminus) antibo...
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