- Clone
- 2S7 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- GEMIN 2, SIP1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
Cat # | Size | Price | Save |
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862901 | 25 µg | ¥23,320 | |
862902 | 100 µg | ¥60,720 |
Gemin 2 is a component of the survival of motor neurons (SMN) macromolecule protein complex, which plays an important role in the assembly and re-structuring of small nucleoproteins and transcriptosomes. The SMN complex localizes to the cytosol and nucleus of eukaryotic cells. Gemin 2 is the only gemin protein that has no homology to any other gemins. Recent studies have suggested that the role of Gemin 2 is to organize 5 Sm proteins into a partial ring for snRNA binding.
Product DetailsProduct Details
- Verified Reactivity
- Human, Mouse, Rat
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
WB - Quality tested
ICC - Reported in the literature, not verified in house - Recommended Usage
-
Each lot of this antibody is quality control tested by Western blotting. For Western blotting, the suggested use of this reagent is 2.0 - 10 µg per ml. It is recommended that the reagent be titrated for optimal performance for each application.
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Application References
(PubMed link indicates BioLegend citation) -
- Battle D, et al. 2007. J Biol Chem. 282(38):27953 (WB, ICC)
- Product Citations
-
- RRID
-
AB_2810755 (BioLegend Cat. No. 862901)
AB_2810755 (BioLegend Cat. No. 862902)
Antigen Details
- Structure
- Gemin 2 is a 280 amino acid protein with an apparent molecular mass of ~ 32 kD.
- Distribution
-
Tissue Distribution: Brain, skeletal muscle, gallbladder, and testis
Cellular Distribution: Nuclear and cytosol - Function
- Gemin 2 is a component of the SMN complex that is essential for the formation of snRNP complexes. It organizes 5 Sm proteins into a partial ring for snRNA binding.
- Interaction
- Gemin 2 binds to SM proteins and is found in complex with other SMN/GEMIN proteins.
- Cell Type
- Neurons
- Biology Area
- Chromatin Remodeling/Epigenetics, Neurodegeneration, Neuroscience, Synaptic Biology, Transcription Factors
- Antigen References
-
- Battle D, et al. 2007. J Biol Chem. 282(38):27953
- Gupta K, et al. 2015. J Biol Chem. 290(33):20185
- Gene ID
- 8487 View all products for this Gene ID 66603 View all products for this Gene ID 84404 View all products for this Gene ID
- UniProt
- View information about Gemin 2 on UniProt.org
Related Pages & Pathways
Pages
Other Formats
View All Gemin 2 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-Gemin 2 | 2S7 | WB |
Compare Data Across All Formats
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Purified anti-Gemin 2
Western blot of purified anti-Gemin 2 antibody (clone 2S7) a...
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