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Purified anti-human CD137 (4-1BB) Recombinant Antibody

Pricing & Availability
Clone
QA18A49 (See other available formats)
Regulatory Status
RUO
Other Names
4-1BB, ILA, CD137, TNFRSF9
Isotype
Mouse IgG1, κ
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Product Citations
publications
QA18A49_PURE_CD137_Antibody_011121
PHA-stimulated (3days) human peripheral blood mononuclear cells were stained with anti-human CD137 (4-1BB) recombinant (clone QA18A49) purified (left) or purified mouse IgG1, κ isotype control (right), followed by goat anti-mouse IgG APC. Cells were co-stained with CD3 PE.
  • QA18A49_PURE_CD137_Antibody_011121
    PHA-stimulated (3days) human peripheral blood mononuclear cells were stained with anti-human CD137 (4-1BB) recombinant (clone QA18A49) purified (left) or purified mouse IgG1, κ isotype control (right), followed by goat anti-mouse IgG APC. Cells were co-stained with CD3 PE.
Cat # Size Price Save
370902 100 µg ¥28,380
Description

CD137 is a 39 kD transmembrane protein also known as 4-1BB. It is expressed on activated T cells. CD137 is a type I membrane protein and a member of the tumor necrosis factor receptor superfamily. CD137 appears to be important for T cell proliferation and survival, and induces monocyte activation through its interaction with 4-1BB ligand.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Recombinant
Host Species
Mouse
Immunogen
Recombinant human CD137 protein
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application Notes

QA18A49 clone of antibody is able to completely block the binding of clone 4B4-1 to CD137 on cell surface.

RRID
AB_2890804 (BioLegend Cat. No. 370902)

Antigen Details

Structure
TNFR superfamily, type I transmembrane protein, 30 kD
Distribution

Activated T cells

Function
T cell costimulation
Ligand/Receptor
4-1BB ligand
Cell Type
Lymphocytes, NK cells, NKT cells, T cells
Biology Area
Adaptive Immunity, Costimulatory Molecules, Immuno-Oncology, Immunology
Molecular Family
CD Molecules
Antigen References
  1. Gruss HJ & Dower SK. 1995. Blood. 85:3378-404.
  2. Sica G & Chen L. 2000. Adv Exp Med Biol. 465:355-62.
  3. Alderson MR, et al. 1994. Eur J Immunol. 24:2219-27.
  4. Schwarz H, et al. 1996. Blood. 87:2839-45.
Gene ID
3604 View all products for this Gene ID
UniProt
View information about CD137 on UniProt.org
Go To Top Version: 1    Revision Date: 11/04/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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