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Purified anti-human CD158a (KIR2DL1) Antibody

Pricing & Availability
Clone
HP-DM1 (See other available formats)
Regulatory Status
RUO
Other Names
NKAT, NKAT1, p58.1, CD158A, KIR221, NKAT-1, KIR-K64
Isotype
Mouse IgG1, κ
Ave. Rating
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Product Citations
publications
HP-DM1_PURE_CD158a_Antibody_041420.png
Human peripheral blood lymphocytes were stained with purified CD158a (KIR2DL1) (clone HP-DM1) (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD56 APC.
  • HP-DM1_PURE_CD158a_Antibody_041420.png
    Human peripheral blood lymphocytes were stained with purified CD158a (KIR2DL1) (clone HP-DM1) (left), or purified mouse IgG1, κ isotype control (right), followed by anti-mouse IgG PE and CD56 APC.
Cat # Size Price Save
374902 100 µg ¥24,640
Description

CD158 molecules, also known as KIRs (killer cell immunoglobulin-like receptors), are a family of transmembrane proteins with either two (KIR2D) or three (KIR3D) Ig-like extracellular domains. Some KIRs with long cytoplasmic domains contain ITIMs and posses inhibitory functions and others with short cytoplasmic region lack ITIM and have activation functions. 15 polymorphic KIR genes have been reported in humans. CD158a is an inhibitory receptor and is mainly expressed on a subset of NK cells and a small population of CD8+ T cells. HP-DM1 is reported to specifically recognizes CD158a.

Product Details
Technical data sheet

Product Details

Verified Reactivity
Human
Antibody Type
Monoclonal
Host Species
Mouse
Immunogen
Human NK Cells
Formulation
Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation
The antibody was purified by affinity chromatography.
Concentration
0.5 mg/mL
Storage & Handling
The antibody solution should be stored undiluted between 2°C and 8°C.
Application

FC - Quality tested
Recommended Usage

Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.

Application References

(PubMed link indicates BioLegend citation)
  1. Meazza R, et al. 2022. HLA. doi: 10.1111 PubMed
  2. Falco M, et al. 2022. HLA. doi: 10.1111 PubMed
RRID
AB_2890805 (BioLegend Cat. No. 374902)

Antigen Details

Structure
Contains two Ig-like extracellular domains
Distribution

NK cells and a small subset of T cells

Function
Inhibits NK cell function
Interaction
NK cells, T cells
Ligand/Receptor
HLA-C
Cell Type
Lymphocytes, NK cells, NKT cells, T cells
Biology Area
Immunology
Antigen References
  1. Zola H, et al. eds. 2007. Leukocyte and Stromal Cell Molecules:The CD Markers. Wiely-Liss A John Wiley & Sons Inc, Publication
Gene ID
3802 View all products for this Gene ID
UniProt
View information about CD158a on UniProt.org
Go To Top Version: 1    Revision Date: 04/14/2020

For Research Use Only. Not for diagnostic or therapeutic use.

 

This product is supplied subject to the terms and conditions, including the limited license, located at www.biolegend.com/terms) ("Terms") and may be used only as provided in the Terms. Without limiting the foregoing, BioLegend products may not be used for any Commercial Purpose as defined in the Terms, resold in any form, used in manufacturing, or reverse engineered, sequenced, or otherwise studied or used to learn its design or composition without express written approval of BioLegend. Regardless of the information given in this document, user is solely responsible for determining any license requirements necessary for user’s intended use and assumes all risk and liability arising from use of the product. BioLegend is not responsible for patent infringement or any other risks or liabilities whatsoever resulting from the use of its products.

 

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This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.

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