- Clone
- S19017D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CC-CKR-8,C-C CKR-8, CCR-8, CC chemokine receptor 8, CDw198, CDw198 antigen, CD198, chemokine (C-C motif) receptor 8, chemokine (C-C) receptor 8, TER1, ChemR1, and CKR-L1
- Isotype
- Mouse IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
CCR8, also known as ChemR1, TER1, and CKR-L1, belongs to the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. CCR8 is expressed on some subsets of T cells, monocytes, macrophages, eosinophils, thymocytes, Langerhans cells, neurons, and vascular smooth muscle cells. Binding with its ligand CCL1, CCR8 plays a role in the regulation of monocyte chemotaxis and thymic cell apoptosis. It has been reported that CCR8 is also a receptor for CCL18. CCR8 is also believed to be an alternative coreceptor to CD4 for HIV-1 infection.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Human CCR8-transfectants
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone S19017D induces complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) on CCR8-transfected cells.
- RRID
-
AB_2904395 (BioLegend Cat. No. 365702)
Antigen Details
- Structure
- Seven hydrophobic transmembrane domains
- Distribution
-
Vascular smooth muscle cells, macrophages, eosinophils, peritoneal macrophages, thymocytes, T cells, Langerhans cells and neurons
- Cell Type
- Tregs
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
- Tiffany HL, et al. 1997. J. Exp. Med. 186:165.
- Goya I, et al. 1998. J. Immunol. 160:1975.
- Lee S, et al. 2000. J. Virol. 74:6946.
- Chensue SW, et al. 2001. J. Exp. Med. 193:573.
- Qu C, et al. 2004. J. Exp. Med. 200:1231.
- Isolam SA, et al. 2003. J. Exp. Med. 210:1889.
- Gene ID
- 1237 View all products for this Gene ID
- UniProt
- View information about CD198 on UniProt.org
Related FAQs
Other Formats
View All CD198 Reagents Request Custom ConjugationDescription | Clone | Applications |
---|---|---|
Purified anti-human CD198 (CCR8) Antibody | S19017D | FC |
PE anti-human CD198 (CCR8) | S19017D | FC |
Ultra-LEAF™ Purified anti-human CD198 (CCR8) | S19017D | FC |
APC anti-human CD198 (CCR8) | S19017D | FC |
FITC anti-human CD198 (CCR8) | S19017D | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD198 (CCR8) Antibody
Human peripheral blood lymphocytes were stained with purifie... Human peripheral blood lymphocytes were stained with Purifie... -
PE anti-human CD198 (CCR8)
Human peripheral blood lymphocytes were stained with CD3 APC... -
Ultra-LEAF™ Purified anti-human CD198 (CCR8)
Human peripheral blood lymphocytes were stained with anti-hu... -
APC anti-human CD198 (CCR8)
Human peripheral blood lymphocytes were stained with anti-hu... -
FITC anti-human CD198 (CCR8)
Human peripheral blood lymphocytes were stained with anti-hu...
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