Purified anti-human CD213a1 IL-13Ralpha1 Antibody anti-CD213a1

Clone: SS12B (See other available formats)
Regulatory Status: RUO
Other Names: NR4, CT19
Isotype: Mouse IgG1, κ
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Product Citations: publications

IL-13Rα1 transfected Burkitt's lymphoma cell line (DND-39) were stained with purified IL-13Rα1 (clone SS12B, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.

Cat #	Size	Price	Save
360402	100 µg	¥59,400

Description

CD213a1, also known as IL-13Rα1, is a subunit of the IL-13R complex. It can heterodimerize with IL-4R and bind IL-13 with high affinity. IL-13Rα1 by itself binds IL-13 with low affinity compared to IL-13Rα2. It is a 48.7 kD, single pass type I membrane protein. It is expressed at low levels on myeloid cells and on activated T and B cells and Th17 cells. It interacts with TYK2 and may lead to activation of JAK1, STAT3, and STAT6 that is induced by IL-13 and IL-4. It has been implicated to have a role in asthma and allergic responses.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Recombinant extracellular domain of human IL-13 receptor α1 chain
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.5 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2562552 (BioLegend Cat. No. 360402)

Antigen Details

Structure: Single-pass type I membrane protein 48.7 kD; forms a heterodimer with IL-4R
Distribution: Expressed at low levels on myeloid cells; also expressed on activated T and B cells, Th17 cells
Function: Functional receptor for IL-13
Interaction: Interacts with TYK2 and can lead to downstream activation of JAK1, STAT3, and STAT6
Ligand/Receptor: IL-13
Cell Type: B cells, T cells, Th17
Biology Area: Immunology, Innate Immunity
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Aman MJ, et al. 1996. J. Biol. Chem. 271:29265.
2. Osawa M, et al. 2000. Immunogenetics. 51:974.
3. Arima K, et al. 2005. J. Biol. Chem. 280:24915.
4. LaPorte SL, et al. 2008. Cell. 132:259.
5. Newcomb DC, et al. 2011. J. Allerg. Clin. Immunol. 127:1006.
Gene ID: 3597 View all products for this Gene ID
UniProt: View information about CD213a1 on UniProt.org

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Cell Surface Flow Cytometry Staining Protocol

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Other Formats

View All CD213a1 Reagents Request Custom Conjugation

Description	Clone	Applications
Purified anti-human CD213a1 (IL-13Rα1)	SS12B	FC
PE anti-human CD213a1 (IL-13Rα1)	SS12B	FC
APC anti-human CD213a1 (IL-13Rα1)	SS12B	FC
PE/Cyanine7 anti-human CD213a1 (IL-13Rα1)	SS12B	FC

Certificate of Analysis

Go To Top Version: 1 Revision Date: 09/19/2013

For Research Use Only. Not for diagnostic or therapeutic use.

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