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- Clone
- A21071B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- CD213a2, IL-13RA2, IL-13R, IL13BP, CT19
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human melanoma cell line, A375, was stained with purified anti-human CD213a2 (IL13Rα2) (clone A21071B) (filled histogram) or purified mouse IgG2b, κ isotype control (open histogram), followed by anti-mouse IgG PE.
CD213a2, also known as IL13Rα2, is a type I transmembrane protein and member of the hematopoietin family. IL13Rα2 is the high affinity receptor for IL-13, but it possibly acts as a decoy receptor to antagonize IL-13Rα1/IL-4Ra-mediated IL-13 biological functions. IL13Rα2 is expressed by fibroblasts, smooth muscle cells, keratinocytes and activated B cells. However, its presence on the cell surface is highly regulated. CD213a2 is also expressed in various types of cancer which makes it an attractive therapeutic target.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant human IL13Rα2, Cys22-Leu342
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2941571 (BioLegend Cat. No. 387002)
Antigen Details
- Structure
- Member of the hematopoietin family, type I transmembrane protein, contains 1 fibronectin type III domain
- Distribution
-
Fibroblasts, smooth muscle cells, keratinocytes, activated B cells
- Function
- Possible decoy receptor, antagonist of CD213a1, internalization of IL-13
- Ligand/Receptor
- IL-13
- Cell Type
- B cells, Fibroblasts
- Biology Area
- Cell Biology, Immunology, Transcription Factors
- Molecular Family
- CD Molecules, Cytokine/Chemokine Receptors
- Antigen References
-
- Mitchell J, et al. 2010. Curr Opin Investig Drugs. 11:527-34.
- Strober W, et al. 2009. Curr Mol Med. 9:740-50.
- Tabata Y, et al. 2007. Curr Allergy Asthma Rep. 7:338-45.
- Gene ID
- 3598 View all products for this Gene ID
- UniProt
- View information about CD213a2 on UniProt.org
Related FAQs
Other Formats
View All CD213a2 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| APC anti-human CD213a2 (IL13Rα2) | A21071B | FC |
| PE anti-human CD213a2 (IL13Rα2) | A21071B | FC |
| Purified anti-human CD213a2 (IL13Rα2) | A21071B | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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APC anti-human CD213a2 (IL13Rα2)
Human melanoma cell line, A375, was stained with anti-human ... -
PE anti-human CD213a2 (IL13Rα2)
Human melanoma cell line, A375, was stained with anti-human ... -
Purified anti-human CD213a2 (IL13Rα2)
Human melanoma cell line, A375, was stained with purified an...
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