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- Clone
- QA20A42 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Kell blood group glycoprotein, Kell blood group antigen Kpbc, KELL and ECE3
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral red blood cells were stained with purified anti-human CD238 recombinant (clone QA20A42) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram), followed by goat-anti-mouse IgG PE.
QA20A42 recognizes human CD238 also known as the kell blood group antigen Kpbc, KELL and ECE3. CD238 is an approximately 115 kD type II transmembrane glycoprotein that is encoded by the KEL gene. CD238 is expressed on erythrocytes, human embryonic stem cell-derived endoderm and on cells from various other tissues, including testis, heart, brain and skeletal muscle. CD238 functions as a zinc endopeptidase that cleaves endothelin-3 into an active form which can function as a vasoconstrictor. Decreased expression of CD238 is associated with the McLeod phenotype as a consequence of losing XK protein expression.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone QA20A42 can completely block the binding of positive clone to target cells.
- RRID
-
AB_2910442 (BioLegend Cat. No. 378702)
Antigen Details
- Structure
- Type II transmembrane glycoprotein 93-115 kD
- Distribution
-
Erythrocytes, human embryonic stem cell-derived endoderm and on cells from various other tissues
- Function
- Zinc endopeptidase that cleaves endothelin-3 into an active form which can function as a vasoconstrictor. Blood transfusions and also specific autoimmune diseases related to Kell antigen recognition.
- Ligand/Receptor
- Laminin α5
- Cell Type
- Embryonic Stem Cells, Erythrocytes
- Biology Area
- Immunology
- Molecular Family
- Blood Group Markers, CD Molecules
- Antigen References
-
- Daniels G. 2009. Hum Genet. 126:729-42.
- Denomme GA. 2015. Immunohematology. 31:14-9.
- Gene ID
- 3792 View all products for this Gene ID
- UniProt
- View information about CD238/KEL on UniProt.org
Related FAQs
Other Formats
View All CD238/KEL Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD238/KEL Recombinant Antibody | QA20A42 | FC |
| PE anti-human CD238/KEL Recombinant Antibody | QA20A42 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD238/KEL Recombinant Antibody
Human peripheral red blood cells were stained with purified ... -
PE anti-human CD238/KEL Recombinant Antibody
Human peripheral red blood cells were stained with anti-huma...
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