Purified anti-human CD267 TACI Antibody anti-CD267

Clone: 1A1 (See other available formats)
Regulatory Status: RUO
Other Names: TNFRSF13B, CD267, Transmembrane Activator and CAML Interactor (TACI)
Isotype: Rat IgG2a, κ
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Product Citations: publications

1A1_Pure_042606 — Human TACI transfected cells stained with purified 1A1, followed by anti-rat IgGs-FITC

Cat #	Size	Price	Save
311902	100 µg	¥45,320

Description

TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs). Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins (BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF-κ B and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.

Product Details

Technical data sheet

Product Details

Verified Reactivity: Human
Reported Reactivity: African Green, Baboon, Cynomolgus, Rhesus
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: TACI-transfected RBL cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤2.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_528979 (BioLegend Cat. No. 311902)

Antigen Details

Structure: Type III transmembrane protein, TNF receptor superfamily, 32 kD
Distribution: B cells, meyloma cells
Function: Negative regulation of B cell function
Ligand/Receptor: BAFF/BLys, April, Syndecan-2
Cell Type: B cells
Biology Area: Costimulatory Molecules, Immunology
Molecular Family: CD Molecules
Antigen References: 1. Gross JA, et al. 2000. Nature 404:995.
2. Wu Y, et al. 2000. J. Biol Chem. 275:35478.
3. Yan M, et al. 2001. Nat. Immunol. 2:638.
4. Hymowitz A, et al. 2005. J. Biol. Chem. 280:7218.
5. Bischof D, et al. 2006. BLOOD 107:3235.
Gene ID: 23495 View all products for this Gene ID
UniProt: View information about CD267 on UniProt.org

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Description	Clone	Applications
Purified anti-human CD267 (TACI)	1A1	FC
Biotin anti-human CD267 (TACI)	1A1	FC
PE anti-human CD267 (TACI)	1A1	FC
PE/Cyanine7 anti-human CD267 (TACI)	1A1	FC
PE/Dazzle™ 594 anti-human CD267 (TACI)	1A1	FC
APC anti-human CD267 (TACI)	1A1	FC
TotalSeq™-A0247 anti-human CD267 (TACI)	1A1	PG
TotalSeq™-C0247 anti-human CD267 (TACI)	1A1	PG
TotalSeq™-B0247 anti-human CD267 (TACI) Antibody	1A1	PG

Certificate of Analysis

Go To Top Version: 2 Revision Date: 08/12/2022

For Research Use Only. Not for diagnostic or therapeutic use.

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