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- Clone
- A20146B (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Ber-H2, Ki-1, TNFRSF8
- Isotype
- Mouse IgG2b, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
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Peripheral blood mononuclear cells were stimulated with anti-CD3/CD28 and recombinant IL-2 (three days) then stained with anti-human CD3 PE and purified anti-human CD30 (clone A20146B) (left) or purified mouse IgG2b, κ isotype control (right) followed by anti-mouse IgG2b APC.
CD30, also known as Ki-1 antigen, lymphoid activation antigen CD30, and tumor necrosis factor receptor superfamily member 8, is a type I transmembrane receptor that contains four TNF receptor domains with an approximate molecular weight of 64 kD. CD30 is highly expressed on Hodgkins and Reed-Sternberg cells as well as activated, but not resting, T and B cells. CD30 has been shown to interact with a number of proteins including TRAF1, TRAF2, TRAF3, TRAF5, NPM-ALK, TRAF-interacting protein, and CD30 ligand (CD153). Signaling through CD30 is thought to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- Recombinant Human CD30
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
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AB_3106029 (BioLegend Cat. No. 306852)
Antigen Details
- Structure
- Type I transmembrane receptor and member of the TNF receptor superfamily that contains 4 TNF receptor domains; predicted molecular weight approximately 64 kD.
- Distribution
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Highly expressed on Hodgkins and Reed-Sternberg cells and activated, but not resting, T cells and B cells.
- Function
- Signaling through CD30 is thought to limit the proliferative potential of autoreactive CD8 effector T cells and protect against autoimmunity.
- Interaction
- TRAF1, TRAF2, TRAF3, TRAF5, NPM-ALK, TRAF-interacting protein, CD30 ligand (CD153)
- Ligand/Receptor
- CD30 Ligand (CD153)
- Cell Type
- B cells, Embryonic Stem Cells, Tregs
- Biology Area
- Immunology, Stem Cells
- Molecular Family
- CD Molecules
- Antigen References
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- Durkop H, et al. 1992. Cell. 68:421-7.
- Aizawa S, et al. 1997. J Biol Chem. 272:2042-5.
- Stein H, et al. 1982. Int J Cancer. 30:445-59.
- Gene ID
- 943 View all products for this Gene ID
- UniProt
- View information about CD30 on UniProt.org
Related FAQs
Other Formats
View All CD30 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD30 | A20146B | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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Purified anti-human CD30
Peripheral blood mononuclear cells were stimulated with anti...
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