United States ($) USD
Austria (€) EUR
Belgium (€) EUR
Finland (€) EUR
France (€) EUR
Germany (€) EUR
Ireland (€) EUR
Japan (¥) JPY
Luxembourg (€) EUR
Netherlands (€) EUR
Switzerland (CHF) CHF
United Kingdom (£) GBP
- Clone
- QA19A19 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- LAIR-1 (Leukocyte-associated Ig-like receptor 1)
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were stained with purified anti-human CD305 recombinant (clone QA19A19) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by goat-anti-mouse IgG Alexa Fluor 647.
CD305, also known as LAIR-1 (leukocyte-associated Ig-like receptor-1), is a 40 kD type I transmembrane glycoprotein. LAIR-1 and LAIR-2 are the only members of the LAIR family in the Ig superfamily. LAIR-1 is an inhibitory molecule characterized by ITIMs in the cytoplasmic domain and collagen ligands. CD305 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells. LAIR-1 functions in the inhibition of cell cytotoxicity, cell activation, proliferation and differentiation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.125 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone QA19A19 can completely block the binding of clone NKTA255 on target cells.
- RRID
-
AB_2910396 (BioLegend Cat. No. 332702)
Antigen Details
- Structure
- 40 kD type I transmembrane protein, cytoplasmic domain contains ITIM motifs, Ig superfamily
- Distribution
-
Expressed on epithelial and mesothelial cells
- Function
- NK cells, T cell, B cells, monocytes, dendritic cells, eosinophils, basophils and mast cells
- Interaction
- Human
- Ligand/Receptor
- Collagens
- Cell Type
- B cells, Basophils, Dendritic cells, Eosinophils, Macrophages, Mast cells, Monocytes, NK cells, T cells
- Biology Area
- Immunology, Inhibitory Molecules, Innate Immunity
- Molecular Family
- CD Molecules
- Antigen References
-
- Meyaard L, et al. 2008. J Leukoc Biol. 83:799-803.
- Lebbink RJ, et al. 2006. J Exp Med. 203:1419-25.
- Gene ID
- 3903 View all products for this Gene ID
- UniProt
- View information about CD305 on UniProt.org
Related FAQs
Other Formats
View All CD305 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD305 Recombinant Antibody | QA19A19 | FC |
| PE anti-human CD305 Recombinant Antibody | QA19A19 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
-
Purified anti-human CD305 Recombinant Antibody
Human peripheral blood lymphocytes were stained with purifie... -
PE anti-human CD305 Recombinant Antibody
Human peripheral blood lymphocytes were stained with anti-hu...
Follow Us