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- Clone
- OV-5B8 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Junctional Adhesion Molecule A, JAM-A, JAM-1, JCAM, F11 R
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
HT29 (Human Colon Cancer cell line) cells were stained with CD321 (clone OV-5B8) FITC (filled histogram) or mouse IgG1, κ FITC isotype control (open histogram).
CD321, also known as Junctional Adhesion Molecule A (JAM-A), JAM-1, or F11 Receptor, is a 32-40 kD type I transmembrane glycoprotein which belongs to the immunoglobin suerfamily. It is expressed broadly on leukocytes, platelets, erythrocytes, and epithelial and endothelial cells. CD321 plays a role in cell adhesion, leukocyte migration, and angiogenesis, through its interactions with integrins, such as LFA-1 and αvβ3 integrins.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Mouse
- Immunogen
- SKOV3 Adenocarcinoma Cell Line
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/ml
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
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AB_10917388 (BioLegend Cat. No. 353502)
Antigen Details
- Structure
- 32-40 kD type I trans-membrane glycoprotein, member of the immunoglobin superfamily
- Distribution
-
Leukocytes, platelets, erythrocytes, epithelial cells, and endothelial cells
- Function
- Cell adhesion, angiogenesis
- Ligand/Receptor
- Integrins
- Cell Type
- Endothelial cells, Epithelial cells, Leukocytes, Platelets
- Biology Area
- Angiogenesis, Cell Adhesion, Cell Biology, Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
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1. Woodfin A, et al. 2007. Blood 110:1848.
2. Cera MR, et al. 2009. J. Cell Sci. 122:268.
3. Fraemohs L, et al. 2004. J. Immunol. 173:6259.
4. Wojcikiewicz EP, et al. 2009. Biophys. J. 96:285. - Gene ID
- 50848 View all products for this Gene ID
- UniProt
- View information about CD321 on UniProt.org
Related FAQs
Other Formats
View All CD321 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD321 (F11R) | OV-5B8 | FC |
| FITC anti-human CD321 (F11R) | OV-5B8 | FC |
| TotalSeq™-A0948 anti-human CD321 (F11R) | OV-5B8 | PG |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD321 (F11R)
HT29 (Human Colon Cancer cell line) cells were stained with ... -
FITC anti-human CD321 (F11R)
HT29 (Human Colon Cancer cell line) cells were stained with ... -
TotalSeq™-A0948 anti-human CD321 (F11R)
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