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- Clone
- W19035D (See other available formats)
- Regulatory Status
- RUO
- Other Names
- SLAMF6, LY108, TCOM, SF2000, NTBA
- Isotype
- Rat IgG2a, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human peripheral blood lymphocytes were surface stained with purified CD352 (NTB-A) (clone W19035D) (filled histogram) or purified rat IgG2a, κ isotype control (open histogram).
NTBA (NK-, T-, and B-cell Antigen) is a 60 kD type I transmembrane glycoprotein. It is a member of Ig superfamily belonging to CD2/CD150 subfamily, also known as SLAMF6 (SLAM family member 6), LY108, TCOM, or SF2000. This antigen is expressed on NK cells, T cells (upregulated upon activation), and B cells. NTBA is its own ligand. The homophilic interaction of NTBA is involved in the induction of NK cytotoxicity, CD28 independent T cell costimulation, triggering Th1 cytokines production, and regulation of B cell tolerance. It may play a role in the regulation of autoimmune diseases.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Monoclonal
- Host Species
- Rat
- Immunogen
- Recombinant human CD352 protein
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2892403 (BioLegend Cat. No. 332302)
Antigen Details
- Structure
- Type I transmembrane tyrosine-phosphorylated glycoprotein, CD2/CD150 subfamily, 60 kD
- Distribution
-
NK cells, T cells, B cells
- Function
- CD28 independent T cell costimulation, induction of NK cell cytotoxicity, regulation of B cell tolerance
- Ligand/Receptor
- NTBA
- Antigen References
-
1. Yigit B, et al. 2019. Cancer Immunol. Res. 10.1158/2326-6066
2. Wu N, et al. 2016. Nature Immunol. 17, 387-396
3. Radomir L, et al. 2017. J. Immunol. 199(8) 2745-2757 - Gene ID
- 114836 View all products for this Gene ID
- UniProt
- View information about CD352 on UniProt.org
Related FAQs
Other Formats
View All CD352 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-human CD352 (NTB-A) Antibody | W19035D | FC |
| Purified anti-human CD352 (NTB-A) Antibody | W19035D | FC |
| PE/Cyanine7 anti-human CD352 (NTB-A) | W19035D | FC |
| APC anti-human CD352 (NTB-A) | W19035D | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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PE anti-human CD352 (NTB-A) Antibody
Human peripheral blood lymphocytes were surface stained with... -
Purified anti-human CD352 (NTB-A) Antibody
Human peripheral blood lymphocytes were surface stained with... -
PE/Cyanine7 anti-human CD352 (NTB-A)
Human peripheral blood lymphocytes were surface stained with... -
APC anti-human CD352 (NTB-A)
Human peripheral blood lymphocytes were surface stained with...
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