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- Clone
- QA18A26 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- Very Early Activation Antigen (VEA), Activation inducer molecule (AIM)
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Cell Activation Cocktail (without Brefeldin A) (Cat. No. 423301) activated human peripheral blood lymphocytes were stained with purified anti-human CD69 recombinant (clone QA18A26) (filled histogram) or purified mouse IgG1, κ isotype control (open histogram) followed by PE goat anti-mouse IgG.
CD69, also known as activation inducer molecule (AIM), very early activation antigen (VEA), and MLR3, is a 27-33 kD type II transmembrane protein. It is a member of the C-type lectin family and expressed as a disulfide-linked homodimer. Other members of this receptor family include NKG2, NKR-P1 CD94, and Ly49. CD69 is transiently expressed on activated leukocytes including T cells, thymocytes, B cells, NK cells, neutrophils, and eosinophils. CD69 is constitutively expressed by a subset of medullary mature thymocytes, platelets, mantle B cells, and certain CD4+ T cells in germinal centers of normal lymph nodes. CD69 is involved in early events of lymphocyte, monocyte, and platelet activation, and has a functional role in redirected lysis mediated by activated NK cells.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
-
FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- Application Notes
-
Clone QA18A26 can completely block the binding of clone FN50 on target cells.
- RRID
-
AB_2927999 (BioLegend Cat. No. 385702)
Antigen Details
- Structure
- C-type lectin, type II glycoprotein, 28/32 kD
- Distribution
-
Activated T cells, B cells, NK cels, Granulocytes, thymocytes, platelets, Langerhans cells
- Function
- Lymphocyte, monocyte, and platelet activation, NK cell killing
- Cell Type
- B cells, Lymphocytes, NK cells, Platelets, T cells, Thymocytes
- Biology Area
- Immunology
- Molecular Family
- Adhesion Molecules, CD Molecules
- Antigen References
-
- Schlossman S, et al. 1995. Leucocyte Typing V. Oxford University Press.
- Marzio R, et al. 1999. Immunopharmacology and immunotoxicology. 21:565-82.
- Gene ID
- 969 View all products for this Gene ID
- UniProt
- View information about CD69 on UniProt.org
Other Formats
View All CD69 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| Purified anti-human CD69 Recombinant Antibody | QA18A26 | FC |
| Cell-Vive™ GMP Ultra-LEAF™ Purified anti-HU CD69 RecAb SF | QA18A26 | FC |
Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
If you need assistance with selecting the best format contact our expert technical support team.
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Purified anti-human CD69 Recombinant Antibody
Cell Activation Cocktail (without Brefeldin A) (Cat. No. 423... -
Cell-Vive™ GMP Ultra-LEAF™ Purified anti-HU CD69 RecAb SF
Human peripheral blood lymphocytes stimulated with BioLegend...
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