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- Clone
- QA18A16 (See other available formats)
- Regulatory Status
- RUO
- Other Names
- B7-1, B7, BB1
- Isotype
- Mouse IgG1, κ
- Ave. Rating
- Submit a Review
- Product Citations
- publications
-
Human B-cell Burkitt's lymphoma cell line Raji was stained with CD80 recombinant (clone QA18A16) purified (filled histogram) or mouse IgG1, κ purified isotype control (open histogram), followed by anti-mouse IgG PE secondary antibody.
CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibitory signal for T cell activation.
Product DetailsProduct Details
- Verified Reactivity
- Human
- Antibody Type
- Recombinant
- Host Species
- Mouse
- Formulation
- Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
- Preparation
- The antibody was purified by affinity chromatography.
- Concentration
- 0.5 mg/mL
- Storage & Handling
- The antibody solution should be stored undiluted between 2°C and 8°C.
- Application
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FC - Quality tested
- Recommended Usage
-
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
- RRID
-
AB_2892452 (BioLegend Cat. No. 370610)
Antigen Details
- Structure
- Ig superfamily, single chain type I transmembrane glycoprotein, 60 kD
- Function
- T cell costimulation
- Ligand/Receptor
- CD28, CD152 (CTLA-4)
- Cell Type
- B cells, Dendritic cells, Macrophages, T cells, Tregs
- Biology Area
- Cell Biology, Costimulatory Molecules, Immunology, Neuroscience, Neuroscience Cell Markers
- Molecular Family
- CD Molecules, Immune Checkpoint Receptors
- Antigen References
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1. Kim GJ, et al. 2012. Immunol. 188:4217-4225.
- Gene ID
- 941 View all products for this Gene ID
- UniProt
- View information about CD80 on UniProt.org
Related FAQs
Other Formats
View All CD80 Reagents Request Custom Conjugation| Description | Clone | Applications |
|---|---|---|
| PE anti-human CD80 Recombinant Antibody | QA18A16 | FC |
| Purified anti-human CD80 Recombinant Antibody | QA18A16 | FC |
| Ultra-LEAF™ Purified anti-human CD80 Recombinant Antibody | QA18A16 | FC |
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Compare Data Across All Formats
This data display is provided for general comparisons between formats.
Your actual data may vary due to variations in samples, target cells, instruments and their settings, staining conditions, and other factors.
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PE anti-human CD80 Recombinant Antibody
Human B-cell Burkitt's lymphoma cell line Raji was stained w... -
Purified anti-human CD80 Recombinant Antibody
Human B-cell Burkitt's lymphoma cell line Raji was stained w... -
Ultra-LEAF™ Purified anti-human CD80 Recombinant Antibody
Human B-cell Burkitt's lymphoma cell line Raji was stained w...
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